(Rac)-PT2399

Modify Date: 2024-04-04 22:24:53

(Rac)-PT2399 structure	Common Name	(Rac)-PT2399
	CAS Number	1672662-07-5	Molecular Weight	419.32
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₀F₅NO₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (Rac)-PT2399

Rac-PT2399 (Compound 10e), the racemate of PT2399, acts as a potent and specific hypoxia-inducible factor 2a (HIF-2α) inhibitor with an IC50 of 0.01 μM[1].

Name	Rac-PT2399

Description	Rac-PT2399 (Compound 10e), the racemate of PT2399, acts as a potent and specific hypoxia-inducible factor 2a (HIF-2α) inhibitor with an IC50 of 0.01 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
Target	IC50: 0.01 μM (HIF-2α)[1]
References	[1]. Wehn PM, et al. Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385). J Med Chem. 2018 Nov 8;61(21):9691-9721.

Molecular Formula	C₁₇H₁₀F₅NO₄S
Molecular Weight	419.32

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (Rac)-PT2399
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Purity: 98.0%
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