2-(Methylamino)propanenitrile

Modify Date: 2024-01-09 12:12:10

2-(Methylamino)propanenitrile Structure
2-(Methylamino)propanenitrile structure
Common Name 2-(Methylamino)propanenitrile
CAS Number 16752-54-8 Molecular Weight 84.11970
Density 0.865g/cm3 Boiling Point 157.2ºC at 760mmHg
Molecular Formula C4H8N2 Melting Point N/A
MSDS N/A Flash Point 48.9ºC

 Names

Name 2-(Methylamino)propanenitrile
Synonym More Synonyms

 Chemical & Physical Properties

Density 0.865g/cm3
Boiling Point 157.2ºC at 760mmHg
Molecular Formula C4H8N2
Molecular Weight 84.11970
Flash Point 48.9ºC
Exact Mass 84.06870
PSA 35.82000
LogP 0.50878
Vapour Pressure 2.79mmHg at 25°C
Index of Refraction 1.409

 MSDS

Material Safety Data Sheet

Section1. Identification of the substance
Product Name: 2-(Methylamino)propanenitrile
Synonyms:

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

Section3. Composition/information on ingredients.
Ingredient name:2-(Methylamino)propanenitrile
CAS number:16752-54-8

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C4H8N2
Molecular weight:84.1

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TZ4905000
CHEMICAL NAME :
Propanenitrile, 2-(methylamino)-
CAS REGISTRY NUMBER :
16752-54-8
LAST UPDATED :
199806
DATA ITEMS CITED :
4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
48 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0545552
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1990 mg/m3/1H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes Blood - hemorrhage
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0545810
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
50100 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Liver - other changes Blood - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0545552

 Safety Information

HS Code 2926909090

 Synthetic Route

~89%

2-(Methylamino)propanenitrile Structure

2-(Methylamino)...

CAS#:16752-54-8

Literature: Zoete, Vincent; Bailly, Fabrice; Catteau, Jean-Pierre; Bernier, Jean-Luc Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 20 p. 2983 - 2988

~%

2-(Methylamino)propanenitrile Structure

2-(Methylamino)...

CAS#:16752-54-8

Literature: Spence,T.W.M.; Tennant,G. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1972 , p. 97 - 102

~%

2-(Methylamino)propanenitrile Structure

2-(Methylamino)...

CAS#:16752-54-8

Literature: I.G. Farbenind. Patent: DE694808 , 1935 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 25, p. 78

~%

2-(Methylamino)propanenitrile Structure

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CAS#:16752-54-8

Literature: du Pont de Nemours and Co. Patent: US2328940 , 1941 ;

~%

2-(Methylamino)propanenitrile Structure

2-(Methylamino)...

CAS#:16752-54-8

Literature: Kurtz,P.; Disselnkoetter,H. Justus Liebigs Annalen der Chemie, 1972 , vol. 764, p. 69 - 93

~%

2-(Methylamino)propanenitrile Structure

2-(Methylamino)...

CAS#:16752-54-8

Literature: Taillades, Jacques Bulletin de la Societe Chimique de France, 1996 , vol. 133, # 1 p. 89 - 100

~%

2-(Methylamino)propanenitrile Structure

2-(Methylamino)...

CAS#:16752-54-8

Literature: Luten Journal of Organic Chemistry, 1938 , vol. 3, p. 590,594 Full Text Show Details Asscher Recueil des Travaux Chimiques des Pays-Bas, 1949 , vol. 68, p. 967 Full Text Show Details Cocker; Lapworth; Walton Journal of the Chemical Society, 1930 , p. 453 Full Text Show Details Cocker; Lapworth; Peters Journal of the Chemical Society, 1931 , p. 1391 Full Text Show Details Biilmann; Berg Bulletin de la Societe Chimique de France, 1934 , vol. <5>1, p. 1658

 Customs

HS Code 2926909090
Summary HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Synonyms

N-Methyl-DL-alanin-nitril
N-cyanoethyl-N-methylamine
DL-2-Methylamino-propionsaeure-nitril
methylaminopropionitrile
DL-2-Methylamino-propionitril
N-methyl-DL-alanine nitrile
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