DL-LAUDANOSINE

Modify Date: 2024-01-07 08:46:36

DL-LAUDANOSINE Structure
DL-LAUDANOSINE structure
 Common Name DL-LAUDANOSINE
CAS Number 1699-51-0 Molecular Weight 357.44300
Density N/A Boiling Point N/A
Molecular Formula C21H27NO4 Melting Point 115℃
MSDS N/A Flash Point N/A
Symbol GHS06
GHS06		 Signal Word Danger

 Use of DL-LAUDANOSINE


DL-Laudanosine, an Atracurium and Cisatracurium metabolite, crosses the blood–brain barrier and may cause excitement and seizure activity[1].

 Names

Name dl-laudanosine
Synonym More Synonyms

 DL-LAUDANOSINE Biological Activity

Description DL-Laudanosine, an Atracurium and Cisatracurium metabolite, crosses the blood–brain barrier and may cause excitement and seizure activity[1].
Related Catalog
In Vivo DL-Laudanosine (Laudanosine) appears to be unique in its ability to produce cerebral stimulation in lightly anaesthetized animals and it is reported to cause arousal from anaesthesia in subconvulsive doses[1]. Animal Model: Male CFLP mice weighing 18-25 g, and male Wistar rats weighing 120-150 g [2]. Dosage: 10-20 mg/kg. Administration: IV. Result: Caused convulsions and hind limb extensions.
References

[1]. V Fodale, et al. Laudanosine, an Atracurium and Cisatracurium Metabolite. Eur J Anaesthesiol. 2002 Jul;19(7):466-73.

[2]. D J Chapple, et al. Cardiovascular and Neurological Effects of Laudanosine. Studies in Mice and Rats, and in Conscious and Anaesthetized Dogs. Br J Anaesth. 1987 Feb;59(2):218-25.

 Chemical & Physical Properties

Melting Point 115℃
Molecular Formula C21H27NO4
Molecular Weight 357.44300
Exact Mass 357.19400
PSA 40.16000
LogP 3.43060

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NX5070000
CHEMICAL NAME :
Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratryl- , (+-)-
CAS REGISTRY NUMBER :
1699-51-0
LAST UPDATED :
198209
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C21-H27-N-O4
MOLECULAR WEIGHT :
357.49
WISWESSER LINE NOTATION :
T66 CNT&J B1R CO1 DO1& C1 HO1 IO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
47 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 20,894,1977

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301 + H311 + H331
Precautionary Statements Missing Phrase - N15.00950417-P261-P280-P302 + P352 + P312-P304 + P340 + P312-P403 + P233
Risk Phrases 26/28-40
Safety Phrases 22-24/25
RIDADR UN 2810
HS Code 2933499090

 Customs

HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

(R)-Laudanosine
LAUDANOSINE,DL-(SH)
(+/-)-LAUDANOSIDE
(+-)-laudanosine
LAUDANOSINE,DL-(SH)(CALL)
LAUDANOSINE,DL
DL-LAUDANOSIDE
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