GS-493
Modify Date: 2024-04-04 19:35:21
GS-493 structure
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Common Name | GS-493 | ||
|---|---|---|---|---|
| CAS Number | 1710337-31-7 | Molecular Weight | 510.437 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H14N6O8S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GS-493GS-493 is a novel potent, selective SHP2 inhibitor with IC50 of 71±15 nM in enzyme assay; displays 29- and 45-fold selectivity against related SHP1 and PTP1B; blocks HGF-stimulated epithelial-mesenchymal transition of human pancreatic adenocarcinoma (HPAF) cells, and inhibits cell colony formation in the NSCLC cell line LXFA 526L in soft agar; inhibits tumor growth in murine xenograft model. |
| Name | GS-493 |
|---|
| Description | GS-493 is a novel potent, selective SHP2 inhibitor with IC50 of 71±15 nM in enzyme assay; displays 29- and 45-fold selectivity against related SHP1 and PTP1B; blocks HGF-stimulated epithelial-mesenchymal transition of human pancreatic adenocarcinoma (HPAF) cells, and inhibits cell colony formation in the NSCLC cell line LXFA 526L in soft agar; inhibits tumor growth in murine xenograft model. |
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| References | References 1. Grosskopf S, et al. ChemMedChem. 2015 May;10(5):815-26. View Related Products by Target Protein Phosphatase/PTP |
| Molecular Formula | C21H14N6O8S |
|---|---|
| Molecular Weight | 510.437 |
| Hazard Codes | Xi |
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- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: GS-493
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: GS-493
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: GS-493
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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