Predonine

Modify Date: 2024-01-01 22:40:19

Predonine structure	Common Name	Predonine
	CAS Number	1715-33-9	Molecular Weight	482.499
	Density	N/A	Boiling Point	689.8ºC at 760mmHg
	Molecular Formula	C₂₅H₃₁NaO₈	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	233.5ºC
	Symbol	GHS07, GHS08	Signal Word	Warning

Name	Prednisolone 21-hemisuccinate sodium salt
Synonym	More Synonyms

Boiling Point	689.8ºC at 760mmHg
Molecular Formula	C₂₅H₃₁NaO₈
Molecular Weight	482.499
Flash Point	233.5ºC
Exact Mass	482.191650
PSA	141.03000
LogP	0.63860
Appearance of Characters	powder \| white
Vapour Pressure	5.08E-22mmHg at 25°C
Storage condition	−20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4153500

CHEMICAL NAME :: Pregna-1,4-diene-3,20-dione, 11-beta,17,21-trihydroxy-, 21-(hydrogen succinate), monosodium salt

CAS REGISTRY NUMBER :: 1715-33-9

LAST UPDATED :: 198910

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C25-H31-O8.Na

MOLECULAR WEIGHT :: 482.55

WISWESSER LINE NOTATION :: L E5 B666 OV AHTTT&J A1 CQ E1 FV1OV2VO FQ &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 770 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 16,63,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 16,63,1982 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 96 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 13,245,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 96 mg/kg

SEX/DURATION :: female 11-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 13,245,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 96 mg/kg

SEX/DURATION :: female 11-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 13,245,1973

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H302-H351
Precautionary Statements	P281
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	S22-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TU4153500

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Solu-Decortin

Meticortelane

MFCD00070045

Prednisolone 21-succinate sodium salt

EINECS 216-995-1

Sodium 4-{[(11β)-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl]oxy}-4-oxobutanoate

butanedioic acid, mono[(11β)-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl] ester, monosodium salt

Predonine

METICORTELONE

11β,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(sodium succinate)

Butanedioic acid, mono[(11β)-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl] ester, sodium salt (1:1)

Prednisolone 21-succinate sodium

11b,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(Sodium Succinate)

Prednisolone sodium succinate

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