| Description |
MFZ 10-7 hydrochloride is a highly potent and selective mGluR5 NAM (negative allosteric modulator), with a Ki of 0.67 nM for rat mGluR5. MFZ 10-7 hydrochloride inhibits cocaine-taking and cocaine-seeking behavior in rats[1].
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| Related Catalog |
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| Target |
rat mGluR5:0.67 nM (Ki)
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| In Vitro |
MFZ 10-7 hydrochloride has approximately 1150- and 3000-fold lower affinity for MAO-B (monoamine oxidase-B enzyme) and TXA2 (thromboxane A2 receptor), respectively, compared to mGluR5[1].
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| In Vivo |
MFZ 10-7 hydrochloride (3 mg/kg, 10 mg/kg; i.p.) inhibits cocaine self-administration in rats[1]. MFZ 10-7 hydrochloride can lower oral sucrose self-administration rate but has no effect on total sucrose intake[1]. Animal Model: Male Long-Evans rats (250-300 g)[1] Dosage: 3 mg/kg, 10 mg/kg Administration: Intraperitoneal injection, single injection Result: Dose-dependently shifted the cocaine dose-response curve downward and inhibited cocaine self-administration maintained by a high dose (0.5 mg/kg/infusion) of cocaine.
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| References |
[1]. Thomas M Keck, et al. A Novel mGluR5 Antagonist, MFZ 10-7, Inhibits Cocaine-Taking and Cocaine-Seeking Behavior in Rats. Addict Biol . 2014 Mar;19(2):195-209.
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