β-catenin-IN-37

Modify Date: 2024-01-20 19:03:30

β-catenin-IN-37 Structure
β-catenin-IN-37 structure
Common Name β-catenin-IN-37
CAS Number 1783856-40-5 Molecular Weight 307.277
Density N/A Boiling Point N/A
Molecular Formula C13H9N9O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of β-catenin-IN-37


β-catenin-IN-37 is a novel potent, and selective small-molecule inhibitor for the β-catenin/Tcf4 protein-protein interaction with Ki of 17 uM; suppresses canonical Wnt signaling, downregulates the expression of Wnt target genes; inhibits the growth of Wnt-activated cancer cells with the IC50 values of 26 uM and 31 uM for SW480 and HCT116 cells, respectively.

 Names

Name β-catenin-IN-37

 β-catenin-IN-37 Biological Activity

Description β-catenin-IN-37 is a novel potent, and selective small-molecule inhibitor for the β-catenin/Tcf4 protein-protein interaction with Ki of 17 uM; suppresses canonical Wnt signaling, downregulates the expression of Wnt target genes; inhibits the growth of Wnt-activated cancer cells with the IC50 values of 26 uM and 31 uM for SW480 and HCT116 cells, respectively.
References References 1. Catrow JL, et al. J Med Chem. 2015 Jun 11;58(11):4678-92. View Related Products by Target Beta-catenin

 Chemical & Physical Properties

Molecular Formula C13H9N9O
Molecular Weight 307.277
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