β-catenin-IN-37 structure
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Common Name | β-catenin-IN-37 | ||
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CAS Number | 1783856-40-5 | Molecular Weight | 307.277 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C13H9N9O | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of β-catenin-IN-37β-catenin-IN-37 is a novel potent, and selective small-molecule inhibitor for the β-catenin/Tcf4 protein-protein interaction with Ki of 17 uM; suppresses canonical Wnt signaling, downregulates the expression of Wnt target genes; inhibits the growth of Wnt-activated cancer cells with the IC50 values of 26 uM and 31 uM for SW480 and HCT116 cells, respectively. |
Name | β-catenin-IN-37 |
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Description | β-catenin-IN-37 is a novel potent, and selective small-molecule inhibitor for the β-catenin/Tcf4 protein-protein interaction with Ki of 17 uM; suppresses canonical Wnt signaling, downregulates the expression of Wnt target genes; inhibits the growth of Wnt-activated cancer cells with the IC50 values of 26 uM and 31 uM for SW480 and HCT116 cells, respectively. |
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References | References 1. Catrow JL, et al. J Med Chem. 2015 Jun 11;58(11):4678-92. View Related Products by Target Beta-catenin |
Molecular Formula | C13H9N9O |
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Molecular Weight | 307.277 |