SHP2 inhibitor 2
Modify Date: 2024-01-04 23:47:43
SHP2 inhibitor 2 structure
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Common Name | SHP2 inhibitor 2 | ||
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| CAS Number | 1799604-71-9 | Molecular Weight | 579.365 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H18IN3O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SHP2 inhibitor 2A nove potent, selective and reversible SHP2 inhibitor with Ki of 0.51 uM; displays 5-fold selectivity over SHP1, and >10-fold secltivity over other PTPs; effectively reduces the EGF-induced ERK1/2 phosphorylation, increased the phosphorylation level of Y118 in paxillin, reduces H1975 cell proliferation in a dose-dependent manner. |
| Name | SHP2 inhibitor 2 |
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| Description | A nove potent, selective and reversible SHP2 inhibitor with Ki of 0.51 uM; displays 5-fold selectivity over SHP1, and >10-fold secltivity over other PTPs; effectively reduces the EGF-induced ERK1/2 phosphorylation, increased the phosphorylation level of Y118 in paxillin, reduces H1975 cell proliferation in a dose-dependent manner. |
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| References | References 1. He R, et al. ACS Med Chem Lett. 2015 Jun 8;6(7):782-6. View Related Products by Target Protein Phosphatase/PTP |
| Molecular Formula | C22H18IN3O6S |
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| Molecular Weight | 579.365 |