Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) amide ammonium salt

Modify Date: 2024-01-19 12:42:10

Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) amide ammonium salt structure	Common Name	Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) amide ammonium salt
	CAS Number	1802078-32-5	Molecular Weight	1532.52
	Density	1.4±0.1 g/cm3	Boiling Point	1895.0±65.0 °C at 760 mmHg
	Molecular Formula	C₆₈H₈₉N₁₅O₂₆	Melting Point	N/A
	MSDS	N/A	Flash Point	1099.9±34.3 °C

Use of Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) amide ammonium salt

Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1[1].

Name	Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) amide ammonium salt
Synonym	More Synonyms

Description	Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1[1].
Related Catalog	Research Areas >> Others
References	[1]. Koike H, et.al. Thimet oligopeptidase cleaves the full-length Alzheimer amyloid precursor protein at a beta-secretase cleavage site in COS cells. J Biochem. 1999 Jul;126(1):235-42.

Density	1.4±0.1 g/cm3
Boiling Point	1895.0±65.0 °C at 760 mmHg
Molecular Formula	C₆₈H₈₉N₁₅O₂₆
Molecular Weight	1532.52
Flash Point	1099.9±34.3 °C
Exact Mass	1531.610352
LogP	2.36
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.600

L-Lysinamide, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-seryl-L-α-glutamyl-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-N6-(2,4-dinitrophen yl)-

N-[(7-Methoxy-2-oxo-2H-chromen-4-yl)acetyl]-L-seryl-L-α-glutamyl-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-L-lysinamide

Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) amide ammonium salt

Use of Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) amide ammonium salt

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