CT7001 hydrochloride
Modify Date: 2024-02-10 23:57:20
CT7001 hydrochloride structure
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Common Name | CT7001 hydrochloride | ||
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| CAS Number | 1805789-54-1 | Molecular Weight | 430.97 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H31ClN6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CT7001 hydrochlorideCT7001 hydrochloride is a selective CDK7 inhibitor, with IC50s of 41 nM and 578 nM for CDK7/CycH/MAT1 and CDK2/cycE1, respectively. |
| Name | 3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)- |
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| Synonym | More Synonyms |
| Description | CT7001 hydrochloride is a selective CDK7 inhibitor, with IC50s of 41 nM and 578 nM for CDK7/CycH/MAT1 and CDK2/cycE1, respectively. |
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| Related Catalog | |
| Target |
CDK7/CycH/MAT1:41 nM (IC50) CDK2/cycE1:578 nM (IC50) |
| In Vitro | CT7001 (ICEC0942) is a selective CDK7 inhibitor, with IC50s of 41 nM and 578 nM for CDK7/CycH/MAT1 and CDK2/cycE1, respectively[1]. |
| Kinase Assay | The purified recombinant CDK2/cycE1 and CDK7/CycH/MAT1 are used in the assay. Kinase assays are performed. Briefly, Rb-CTF and RNA Polymerase II peptide is used for CDK2 and CDK7 kinase assays, respectively. A luciferase assay is used to determine ATP remaining at the end of the kinase reaction, which provides a measure of kinase activity. GraphPad Prism Software is used to generate the IC50 values for each CDK[1]. |
| References |
| Molecular Formula | C22H31ClN6O |
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| Molecular Weight | 430.97 |
| Storage condition | 2-8℃ |
| PPDA-001 HCL SALT |
| CT7001 hydrochloride |