GPA 512

Modify Date: 2024-09-18 14:42:32

GPA 512 Structure
GPA 512 structure
Common Name GPA 512
CAS Number 1808115-35-6 Molecular Weight 371.448
Density N/A Boiling Point N/A
Molecular Formula C17H25NO6S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GPA 512


The orally bioavailable prodrug of Galiellalactone, a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes; increases the plasma exposure of the active parent compound 20-fold compared to Galiellalactone; significantly reduces tumor growth in DU145 xenograft tumors.

 Names

Name GPA 512

 GPA 512 Biological Activity

Description The orally bioavailable prodrug of Galiellalactone, a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes; increases the plasma exposure of the active parent compound 20-fold compared to Galiellalactone; significantly reduces tumor growth in DU145 xenograft tumors.
References References 1. Escobar Z, et al. J Med Chem. 2016 May 26;59(10):4551-62. View Related Products by Target STAT

 Chemical & Physical Properties

Molecular Formula C17H25NO6S
Molecular Weight 371.448