2-bromohexadecanoic acid

Modify Date: 2024-01-02 17:32:34

2-bromohexadecanoic acid Structure
2-bromohexadecanoic acid structure
Common Name 2-bromohexadecanoic acid
CAS Number 18263-25-7 Molecular Weight 335.32
Density 1.1±0.1 g/cm3 Boiling Point 403.4±18.0 °C at 760 mmHg
Molecular Formula C16H31BrO2 Melting Point 52-54 °C
MSDS Chinese USA Flash Point 197.8±21.2 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 2-bromohexadecanoic acid


2-Bromohexadecanoic acid (2-Bromopalmitic acid) can be converted to 2-bromopalmitate (2-BP). 2-BP is a palmitoylation inhibitor targeting DHHC (Asp-His-His-Cys) protein palmitoyltransferase. 2-BP inhibits palmitoylation of GSDME-C during pyroptosis and inhibits BAK/BAX-Caspase 3-GSDME pathway-mediated pyroptosis[1].

 Names

Name 2-bromohexadecanoic acid
Synonym More Synonyms

 2-bromohexadecanoic acid Biological Activity

Description 2-Bromohexadecanoic acid (2-Bromopalmitic acid) can be converted to 2-bromopalmitate (2-BP). 2-BP is a palmitoylation inhibitor targeting DHHC (Asp-His-His-Cys) protein palmitoyltransferase. 2-BP inhibits palmitoylation of GSDME-C during pyroptosis and inhibits BAK/BAX-Caspase 3-GSDME pathway-mediated pyroptosis[1].
Related Catalog
References

[1]. Hu L, et al. Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate. Cell Death Dis. 2020 Apr 24;11(4):281.  

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 403.4±18.0 °C at 760 mmHg
Melting Point 52-54 °C
Molecular Formula C16H31BrO2
Molecular Weight 335.32
Flash Point 197.8±21.2 °C
Exact Mass 334.150726
PSA 37.30000
LogP 7.76
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.480

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2915900090

 Synthetic Route

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2-bromohexadecanoic acid Structure

2-bromohexadeca...

CAS#:18263-25-7

Literature: Journal of the Chemical Society, , vol. 87, p. 1901 Chemische Berichte, , vol. 25, p. 486 Chemische Berichte, , vol. 24, p. 939

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2-bromohexadecanoic acid Structure

2-bromohexadeca...

CAS#:18263-25-7

Literature: Yakugaku Zasshi, , vol. 61, p. 406;dtsch.Ref.S.127 Chem.Abstr., , p. 9356

 Customs

HS Code 2915900090
Summary 2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

 Articles30

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 Synonyms

Hexadecanoic acid, 2-bromo-
2-bromopalmitate
2-Bromopalmitic acid
UNII:7EI4G5X28Z
2-bromopalmitate,(+-)-isomer
2-bromo-hexadecanoic acid
Hexadecanoic acid,2-bromo
EINECS 242-137-0
MFCD00004215
bromopalmitic acid
2-Bromohexadecanoic acid
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