Epoxyazadiradione

Modify Date: 2024-03-26 22:51:48

Epoxyazadiradione Structure
Epoxyazadiradione structure
Common Name Epoxyazadiradione
CAS Number 18385-59-6 Molecular Weight 466.56600
Density 1.25g/cm3 Boiling Point 569.1ºC at 760mmHg
Molecular Formula C28H34O6 Melting Point N/A
MSDS N/A Flash Point 298ºC

 Use of Epoxyazadiradione


Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. Epoxyazadiradione inhibits the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF)) non-competitively in a reversible fashion (Ki, 2.11-5.23 μM). Epoxyazadiradione has the potential against proinflammatory reactions induced by MIF of both malaria parasites and human[1].

 Names

Name epoxyazadiradione
Synonym More Synonyms

 Epoxyazadiradione Biological Activity

Description Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. Epoxyazadiradione inhibits the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF)) non-competitively in a reversible fashion (Ki, 2.11-5.23 μM). Epoxyazadiradione has the potential against proinflammatory reactions induced by MIF of both malaria parasites and human[1].
Related Catalog
References

[1]. Alam A, et al. Novel anti-inflammatory activity of epoxyazadiradione against macrophage migration inhibitory factor: inhibition of tautomerase and proinflammatory activities of macrophage migration inhibitory factor. J Biol Chem. 2012;287(29):24844-24861.

 Chemical & Physical Properties

Density 1.25g/cm3
Boiling Point 569.1ºC at 760mmHg
Molecular Formula C28H34O6
Molecular Weight 466.56600
Flash Point 298ºC
Exact Mass 466.23600
PSA 86.11000
LogP 4.62910
Vapour Pressure 5.76E-13mmHg at 25°C
Index of Refraction 1.582

 Synonyms

ethyl 2,3-epoxybutyrate
ethyl 2,3-epoxybutanoate
Epoxyazadiradione
2,3-Epoxybutyric acid,ethyl ester
epoxy-2,3 butanoate d'ethyle
BUTYRIC ACID,2,3-EPOXY-,ETHYL ESTER
2,3-Epoxybuttersaeure-ethylester
3-methyl-oxiranecarboxylic acid ethyl ester
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