AF12198

Modify Date: 2024-04-03 09:16:05

AF12198 Structure
AF12198 structure
 Common Name AF12198
CAS Number 185413-30-3 Molecular Weight 1895.12000
Density 1.354 g/cm3 Boiling Point N/A
Molecular Formula C96H123N19O22 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AF12198


AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC50=8 nM) but not the human type II receptor (IC50=6.7 µM) or the murine type I receptor (IC50>200 µM). AF12198 inhibits IL-1-induced IL-8 production (IC50=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC50=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo[1].

 Names

Name af 12198
Synonym More Synonyms

 AF12198 Biological Activity

Description AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC50=8 nM) but not the human type II receptor (IC50=6.7 µM) or the murine type I receptor (IC50>200 µM). AF12198 inhibits IL-1-induced IL-8 production (IC50=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC50=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo[1].
Related Catalog
Target

IC50: 8 nM (human IL1R1)[1]

References

[1]. F Aimbire, et al. Low level laser therapy (LLLT) decreases pulmonary microvascular leakage, neutrophil influx and IL-1beta levels in airway and lung from rat subjected to LPS-induced inflammation. Inflammation

[2]. A L Akeson, et al.AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL-1. J Biol Chem. 1996 Nov 29;271(48):30517-23.

 Chemical & Physical Properties

Density 1.354 g/cm3
Molecular Formula C96H123N19O22
Molecular Weight 1895.12000
Exact Mass 1893.91000
PSA 625.88000
LogP 5.63910

 Synonyms

Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-L-azetidine-2-carbonyl-Tyr-Ala-Leu-Pro-Leu-NH2
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Chemsrc provides AF12198(CAS#:185413-30-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of AF12198 are included as well.>> amp version: AF12198

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