Foliglurax

Modify Date: 2024-01-10 11:48:31

Foliglurax Structure
Foliglurax structure
Common Name Foliglurax
CAS Number 1883329-51-8 Molecular Weight 421.51
Density N/A Boiling Point N/A
Molecular Formula C23H23N3O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Foliglurax


Foliglurax (PXT002331) is a highly selective and potent, brain-penetrant mGluR4 positive allosteric modulator (PAM) with an EC50 of 79 nM[1]. Antiparkinsonian effect[1].

 Names

Name Foliglurax

 Foliglurax Biological Activity

Description Foliglurax (PXT002331) is a highly selective and potent, brain-penetrant mGluR4 positive allosteric modulator (PAM) with an EC50 of 79 nM[1]. Antiparkinsonian effect[1].
Related Catalog
Target

mGlu4:79 nM (EC50)

In Vitro Foliglurax, a highly selective and potent mGlu4 receptor PAM with a marked brain-penetrance feature, might revolutionize the field of mGlu4 receptor drug targeting in CNS disorders[2].
References

[1]. Charvin D, et al. Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4. J Med Chem. 2017 Oct 26;60(20):8515-8537.

[2]. Volpi C, et al. Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4. Expert Opin Drug Discov. 2018 May;13(5):411-423.

 Chemical & Physical Properties

Molecular Formula C23H23N3O3S
Molecular Weight 421.51
Storage condition 2-8°C