Naringin dihydrochalcone

Modify Date: 2024-01-03 12:39:55

Naringin dihydrochalcone Structure
Naringin dihydrochalcone structure
 Common Name Naringin dihydrochalcone
CAS Number 18916-17-1 Molecular Weight 582.55
Density 1.6±0.1 g/cm3 Boiling Point 916.8±65.0 °C at 760 mmHg
Molecular Formula C27H34O14 Melting Point 131-132°C
MSDS N/A Flash Point 302.7±27.8 °C

 Use of Naringin dihydrochalcone


Naringin Dihydrochalcone is an artificial sweetener derived from naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin suppresses NF-κB signaling pathway.

 Names

Name Naringin dihydrochalcone
Synonym More Synonyms

 Naringin dihydrochalcone Biological Activity

Description Naringin Dihydrochalcone is an artificial sweetener derived from naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin suppresses NF-κB signaling pathway.
Related Catalog
Target

NF-κB

In Vitro Naringin suppresses NF-κ B signaling pathway activation. Naringenin inhibits high glucose-induced proliferation, inflammatory reaction and oxidative stress injury in HBZY-1 cells[1]. Naringin inhibits AGS cancer cell proliferation in a dose- and time-dependent manner. Phosphorylation of PI3K and its activated downstream targets p-Akt and p-mTOR are significantly decreased at 2 mM in Naringin-treated AGS cells. Naringin induces autophagic cell death in AGS cells. Naringin activated the autophagy related protein in AGS cells[2]. Naringin protects PC12 cells from 3-NP neurotoxicity. The lactate dehydrogenase release is decreased upon naringin treatment in 3-NP-induced PC12 cells. Naringin treatment enhances the antioxidant defense by increasing the activities of enzymatic antioxidants and the level of reduced glutathione[3].
In Vivo Treatment with naringin significantly alleviates renal injury in diabetic rats and increases diabetic rats body weight significantly. Administration of naringin effectively alleviates the collagen deposition and renal interstitial fibrosis in diabetic rats. Treatment with naringin could result in decreased levels of ROS and MDA and increased activities of SOD and GSH-Px[1]. Oral administration of naringin significantly improves the learning and memory abilities. Naringin significantly enhances insulin signaling pathway[3].
Cell Assay HBZY-1 cells are plated into 96-well plates and pretreated with various concentrations(1, 5, 10, 25, 50, 100 μM) of naringin for 2 h. Then cells are treated with 30 mM glucose for 24 h. The control group is added sterile normal saline in the same volume. After treatment, all the wells are incubated with 20 μl of 5 mg/ml MTT for 4 h at 37°C. Subsequently, 100 μl of DMSO are used to dissolve the formed formazan crystals after removal of the supernatant. The result is recorded at 490 nm on a microplate reader[1].
Animal Admin Rats: The rats are randomly divided into six groups: control, naringin (80 mg/kg), STZ, STZ+naringin (20 mg/kg), STZ+naringin (40 mg/kg), STZ+naringin(80 mg/kg). The rats in the STZ and STZ+naringin groups are intraperitoneally injected with STZ (65 mg/kg). The control and naringin groups are intraperitoneally injected with 0.1 M citrate buffer of same volume. After injection of STZ for 3 and 5 days, blood glucose levels are measured by tail vein puncture blood sampling[1]. Mice: Sixty 4-week-old male mice are randomized into four groups and fed for 20 weeks with either control diet or high-fat diet chow. Mice are dosed with 100 mg/kg of naringin daily. Mice body weight and food intake are weekly measured. Following behavioral assessment, animals are deeply anesthetized with isoflurane and sacrificed by decapitation after fasting for at least 5 h. Their plasma is collected for further analysis[4].
References

[1]. Chen F, et al. Naringin Alleviates Diabetic Kidney Disease through Inhibiting Oxidative Stress and Inflammatory Reaction. PLoS One. 2015 Nov 30;10(11):e0143868.

[2]. Raha S, et al. Naringin induces autophagy-mediated growth inhibition by downregulating the PI3K/Akt/mTOR cascade via activation of MAPK pathways in AGS cancer cells. Int J Oncol. 2015 Sep;47(3):1061-9.

[3]. Kulasekaran G, et al. Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells. Mol Cell Biochem. 2015 Nov;409(1-2):199-211.

[4]. Wang D, et al. Naringin Improves Neuronal Insulin Signaling, Brain Mitochondrial Function, and Cognitive Function in High-Fat Diet-Induced Obese Mice. Cell Mol Neurobiol. 2015 Oct;35(7):1061-71.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 916.8±65.0 °C at 760 mmHg
Melting Point 131-132°C
Molecular Formula C27H34O14
Molecular Weight 582.55
Flash Point 302.7±27.8 °C
PSA 236.06000
LogP 3.38
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.696

 Safety Information

Hazard Codes Xi
Risk Phrases R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases S26-S36
WGK Germany 3

 Synthetic Route

Naringin structure

Naringin

CAS#:10236-47-2

~%

Naringin dihydrochalcone Structure

Naringin dihydr...

CAS#:18916-17-1

Literature: Journal of Agricultural and Food Chemistry, , vol. 51, # 11 p. 3309 - 3312
NARINGIN CHALCONE structure

NARINGIN CHALCONE

CAS#:50376-43-7

~%

Naringin dihydrochalcone Structure

Naringin dihydr...

CAS#:18916-17-1

Literature: Annali di Chimica (Rome, Italy), , vol. 49, p. 1929,1936

 Synonyms

Naringin dihydrochal
Senior saccharin
Naringin-dihydro-chalkon
2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)
MFCD08436145
Naringin dihydrochalcone
1-Propanone, 1-[4-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-L-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-
Naringin Dihydrochalcone(Naringin DC)
NARINGINDIHYDROHALCONE
Naringin DC
3,5-Dihydroxy-4-[3-(4-hydroxyphenyl)propanoyl]phenyl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-L-glucopyranoside
NARINGIN DIHYDOROCHALCONE
NAGINGINDIHYDROCHALCONE
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Naringin dihydrochalcone suppliers

Price: $119/10mM*1mLinDMSO

Reference only. check more Naringin dihydrochalcone price

Related Compounds: More...
Naringin Hydrate
132203-74-8
Naringin 4'-glucoside
17257-21-5
Naringin
10236-47-2
Naringin 6''-acetate
139934-60-4
NARINGIN CHALCONE
50376-43-7
Hesperidin dihydrochalcone
35573-79-6
Neosperidin dihydrochalcone
20702-77-6
eriodictyol dihydrochalcone
57765-66-9
Hesperitin dihydrochalcone glucoside
21940-36-3
Chemsrc provides Naringin dihydrochalcone(CAS#:18916-17-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Naringin dihydrochalcone are included as well.>> amp version: Naringin dihydrochalcone

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved