Methanesulfonic acid,propyl ester

CAS Number1912-31-8

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Section II.Composition and Information on Ingredients
Toxicology Data
Chemical NameCAS Number Percent (%)TLV/PEL
1912-31-8 Min. 98.0 (GC) Not available.Not available.
Propyl Methanesulfonate

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Section III. Hazards Identification
Acute Health EffectsHarmful if ingested or inhaled. Minimize exposure to this material. Severe overexposure can result in injury or death.
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
Chronic Health EffectsCARCINOGENIC EFFECTS : Not available.
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Reproductive effects.
Rat TDLo Intraperitoneal 400 mg/kg, male 1 day prior to mating
Toxic Effects:
Effects on Fertility - Male fertility index
Mouse TDLo Intraperitoneal 600 mg/kg, female 1 day prior to mating
Toxic Effects:
Effects on Fertility - Litter size
Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.

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Section IV.First Aid Measures
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
Eye Contact
minutes. Get medical attention.
In case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing
Skin Contact
before reuse. Thoroughly clean shoes before reuse. Get medical attention.
InhalationIf the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or
waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
improve.
IngestionINDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.
Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic
material was ingested; the absence of such signs, however, is not conclusive.

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Section V.Fire and Explosion Data
Not available.
May be combustible at high temperature.Auto-Ignition
Flammability
Flammable LimitsNot available.
Flash PointsNot available.
Combustion ProductsThese products are toxic carbon oxides (CO, CO2), sulfur oxides (SOx).
Fire Hazards
Not available.
Risks of explosion of the product in presence of mechanical impact: Not available.
Explosion Hazards
Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
and Instructions
Consult with local fire authorities before attempting large scale fire-fighting operations.
Continued on Next Page
Propyl Methanesulfonate

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Section VI.Accidental Release Measures
Spill CleanupHarmful material. Possibly mutagenic material.
Absorb with an inert material and put the spilled material in an appropriate waste disposal. Consult federal, state, and/or local
Instructions
authorities for assistance on disposal.

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Section VII. Handling and Storage
Handling and StorageHARMFUL. POSSIBLE MUTAGEN. Keep away from heat. Mechanical exhaust required. When not in use, tightly seal the
container and store in a dry, cool place. Avoid excessive heat and light. Do not breathe gas/fumes/ vapor/spray.
Information
Always store away from incompatible compounds such as oxidizing agents.

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Section VIII. Exposure Controls/Personal Protection
Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective
Engineering Controls
threshold limit value. Ensure that eyewash station and safety shower is proximal to the work-station location.
Splash goggles. Lab coat. Vapor respirator. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a
Personal Protection
specialist BEFORE handling this product. Be sure to use a MSHA/NIOSH approved respirator or equivalent.
Exposure LimitsNot available.

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Section IX. Physical and Chemical Properties
Liquid. (Clear, colorless ~ light yellow.)Solubility
Physical state @ 20°CNot available.
1.15 (water=1)
Specific Gravity
138.19
Molecular WeightPartition CoefficientNot available.
Boiling Point110°C (230°F) @ 20 mmHgVapor PressureNot available.
Not available.Not available.
Melting PointVapor Density
1.42VolatilityNot available.
Refractive Index
Not available.
Critical TemperatureNot available.Odor
ViscosityNot available.TasteNot available.

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Section X.Stability and Reactivity Data
Stability

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This material is stable if stored under proper conditions. (See Section VII for instructions)
Conditions of InstabilityAvoid excessive heat and light.
Incompatibilities
Reactive with oxidizing agents.

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Section XI. Toxicological Information
PB2680000
RTECS Number
Routes of ExposureEye Contact. Ingestion. Inhalation.
Not available.
Toxicity Data
Chronic Toxic EffectsCARCINOGENIC EFFECTS : Not available.
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Reproductive effects.
Rat TDLo Intraperitoneal 400 mg/kg, male 1 day prior to mating
Toxic Effects:
Effects on Fertility - Male fertility index
Mouse TDLo Intraperitoneal 600 mg/kg, female 1 day prior to mating
Toxic Effects:
Effects on Fertility - Litter size
Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.
Harmful if ingested or inhaled. Minimize exposure to this material. Severe overexposure can result in injury or death.
Acute Toxic Effects
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
Continued on Next Page
Propyl Methanesulfonate

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Section XII.Ecological Information
EcotoxicityNot available.
Not available.
Environmental Fate

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Section XIII. Disposal Considerations
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a
Waste Disposal
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
federal, state and local regulations when disposing of the substance.

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Section XIV. Transport Information
DOT ClassificationNot a DOT controlled material (United States).
Not applicable.
PIN Number
Proper Shipping NameNot applicable.
Not applicable.
Packing Group (PG)
DOT Pictograms

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Section XV. Other Regulatory Information and Pictograms
TSCA Chemical InventoryThis product is NOT on the EPA Toxic Substances Control Act (TSCA) inventory. The following notices are required by 40
CFR 720.36 (C) for those products not on the inventory list:
(EPA)
(i) These products are supplied solely for use in research and development by or under the supervision of a technically
qualified individual as defined in 40 CFR 720.0 et sec.
(ii) The health risks of these products have not been fully determined. Any information that is or becomes available will be
supplied on an MSDS sheet.
WHMIS ClassificationNot available.
(Canada)
EINECS Number (EEC) 217-619-9
EEC Risk StatementsR20/21/22- Harmful by inhalation, in contact with skin and if swallowed.
R46- May cause heritable genetic damage.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

DATA ITEMS CITED :

13

MOLECULAR FORMULA :

C4-H10-O3-S

MOLECULAR WEIGHT :

138.20

WISWESSER LINE NOTATION :

WS1&O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

400 mg/kg

SEX/DURATION :

male 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

600 mg/kg

SEX/DURATION :

female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :

DNA damage

TYPE OF TEST :

Micronucleus test

TYPE OF TEST :

Specific locus test

MUTATION DATA

TEST SYSTEM :

Rodent - mouse

DOSE/DURATION :

50 mg/kg

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 11,35,1971