CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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QJ6500000
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CHEMICAL NAME :
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1,3-Naphthalenedisulfonic acid, 7-hydroxy-8-(phenylazo)-, disodium salt
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CAS REGISTRY NUMBER :
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1936-15-8
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LAST UPDATED :
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199707
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DATA ITEMS CITED :
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17
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MOLECULAR FORMULA :
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C16-H10-N2-O7-S2.2Na
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MOLECULAR WEIGHT :
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452.38
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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26250 mg/kg/15W-C
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TOXIC EFFECTS :
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Liver - changes in liver weight Endocrine - changes in spleen weight Blood - normocytic anemia
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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27300 mg/kg/13W-C
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TOXIC EFFECTS :
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Blood - changes in spleen
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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136 gm/kg/13W-C
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TOXIC EFFECTS :
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Blood - changes in spleen
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - pig
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DOSE/DURATION :
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2800 mg/kg/16W-C
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TOXIC EFFECTS :
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Endocrine - changes in spleen weight Blood - normocytic anemia Blood - other changes
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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28 gm/kg
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SEX/DURATION :
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male 16 week(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - testes, epididymis, sperm duct
MUTATION DATA
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TYPE OF TEST :
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Cytogenetic analysis
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TEST SYSTEM :
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Rodent - hamster Ovary
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DOSE/DURATION :
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20 umol/L/5H (Continuous)
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REFERENCE :
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ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,181,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,181,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2138 No. of Facilities: 613 (estimated) No. of Industries: 9 No. of Occupations: 24 No. of Employees: 11575 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2138 No. of Facilities: 588 (estimated) No. of Industries: 11 No. of Occupations: 32 No. of Employees: 27936 (estimated) No. of Female Employees: 12401 (estimated)
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CAS#:2684-02-8
CAS#:148-75-4
