2-Deoxy-D-lyxo-hexose

Modify Date: 2024-01-08 19:55:27

2-Deoxy-D-lyxo-hexose Structure
2-Deoxy-D-lyxo-hexose structure
 Common Name 2-Deoxy-D-lyxo-hexose
CAS Number 1949-89-9 Molecular Weight 164.156
Density 1.4±0.1 g/cm3 Boiling Point 456.7±45.0 °C at 760 mmHg
Molecular Formula C6H12O5 Melting Point 107-110 °C(lit.)
MSDS N/A Flash Point 244.1±25.2 °C

 Use of 2-Deoxy-D-lyxo-hexose


2-Deoxy-D-galactose is a glucose analog. 2-Deoxy-D-galactose inhibits glycolysis to inhibits tumor growth. 2-Deoxy-D-galactose is a substance interfering with the fucosylation of glycomacromolecules and impairing memory consolidation in various learning tasks. 2-Deoxy-d-galactose hinders glycoprotein fucosylation in vivo[1].

 Names

Name 2-deoxy-D-galactose
Synonym More Synonyms

 2-Deoxy-D-lyxo-hexose Biological Activity

Description 2-Deoxy-D-galactose is a glucose analog. 2-Deoxy-D-galactose inhibits glycolysis to inhibits tumor growth. 2-Deoxy-D-galactose is a substance interfering with the fucosylation of glycomacromolecules and impairing memory consolidation in various learning tasks. 2-Deoxy-d-galactose hinders glycoprotein fucosylation in vivo[1].
Related Catalog
In Vitro 2-Deoxy-D-galactose (1 mM/L; 5 h) is rapid phosphorylation during the first 30 min and decreases to approximately 20% of this rate during the subsequent hours in ascites hepatoma cells[4].
In Vivo 2-Deoxy-D-galactose (380 mg/kg; i.p.; for 6 times) strongly decreases contents of UMP, UDPG, and UDP galactose in rat livers[1]. 2-Deoxy-D-galactose (2-8 μM; intracerebroventricularly injection; once) shows PAR impairment 30 min before the acquisition trial a dose of 4 μM and 15 min delay after do-gal administration[3]. Animal Model: Male adult Wistar rats with passive avoidance response (PAR) acquisition trial[3] Dosage: 2, 4 and 8 μM Administration: Intracerebroventricularly injection; 2-8 μM; once Result: Exhibited PAR disruption at a dose of 4 μM.
References

[1]. Keppler DO, et al. The trapping of uridine phosphates by D-galactosamine. D-glucosamine, and 2-deoxy-D-galactose. A study on the mechanism of galactosamine hepatitis. Eur J Biochem. 1970 Dec;17(2):246-53.

[2]. Krug M, et al. The amnesic substance 2-deoxy-D-galactose suppresses the maintenance of hippocampal LTP. Brain Res. 1991 Feb 1;540(1-2):237-42.

[3]. Lorenzini CG, et al. 2-Deoxy-D-galactose effects on passive avoidance memorization in the rat. Neurobiol Learn Mem. 1997 Nov;68(3):317-24.

[4]. Smith DF, Keppler DO. 2-Deoxy-D-galactose metabolism in ascites hepatoma cells results in phosphate trapping and glycolysis inhibition. Eur J Biochem. 1977 Feb 15;73(1):83-92.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 456.7±45.0 °C at 760 mmHg
Melting Point 107-110 °C(lit.)
Molecular Formula C6H12O5
Molecular Weight 164.156
Flash Point 244.1±25.2 °C
Exact Mass 164.068466
PSA 90.15000
LogP -3.07
Vapour Pressure 0.0±2.5 mmHg at 25°C
Index of Refraction 1.534

 Safety Information

Hazard Codes Xi: Irritant;
Risk Phrases 20/21/22-36/37/38
Safety Phrases S24/25
WGK Germany 3
HS Code 2912491000

 Synthetic Route

2-deoxy-4,5-O-isopropylidene-D-lyxo-hexose dimethyl acetal structure

2-deoxy-4,5-O-i...

CAS#:73991-08-9

~84%

2-Deoxy-D-lyxo-hexose Structure

2-Deoxy-D-lyxo-...

CAS#:1949-89-9

Literature: Wong, Margaret Y. H.; Gray, Gary R. Carbohydrate Research, 1980 , vol. 80, p. 87 - 98
2,3:4,5-di-O-isopropylidene-D-glucose diethyl dithioacetal structure

2,3:4,5-di-O-is...

CAS#:6207-30-3

~%

2-Deoxy-D-lyxo-hexose Structure

2-Deoxy-D-lyxo-...

CAS#:1949-89-9

Literature: Carbohydrate Research, , vol. 80, p. 87 - 98
2-deoxy-4,5-O-isopropylidene-D-lyxo-hexose diethyl dithioacetal structure

2-deoxy-4,5-O-i...

CAS#:73982-55-5

~%

2-Deoxy-D-lyxo-hexose Structure

2-Deoxy-D-lyxo-...

CAS#:1949-89-9

Literature: Carbohydrate Research, , vol. 80, p. 87 - 98
2-deoxy-4,5-O-isopropylidene-D-lyxo-hex-1-enose diethyl dithioacetal structure

2-deoxy-4,5-O-i...

CAS#:73982-54-4

~%

2-Deoxy-D-lyxo-hexose Structure

2-Deoxy-D-lyxo-...

CAS#:1949-89-9

Literature: Carbohydrate Research, , vol. 80, p. 87 - 98
((4R,5R)-5-((R)-1-acetoxy-3,3-dimethoxypropyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl acetate structure

((4R,5R)-5-((R)...

CAS#:73982-59-9

~%

2-Deoxy-D-lyxo-hexose Structure

2-Deoxy-D-lyxo-...

CAS#:1949-89-9

Literature: Carbohydrate Research, , vol. 80, p. 87 - 98

 Customs

HS Code 2912491000
Summary 2912491000. other aldehyde-alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

 Synonyms

2-DEOXY-D-LYXOHEXOSE
2-deoxy-galactose
2-deoxy-lyxo-hexose
2-Deoxy-B-D-Lyxo-Hexose
EINECS 217-765-3
Deoxygalactose
2-Dexoy-D-Lyxohexose
D-2-Desoxygalactose
D-2-deoxygalactose
D-lyxo-Hexose, 2-deoxy-
2-Deoxy-D-GalaCLose
D-lyxo-Hexose,2-deoxy
lyxo-Hexose, 2-deoxy-
2-Deoxy-D-Galactopyranose
2-Deoxy-D-galactose
MFCD00014649
DEOXY-D-GALACTOSE,2
2-deoxy-D-talose
(3R,4R,5R)-3,4,5,6-Tetrahydroxyhexanal
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