BC-1485
Modify Date: 2024-04-02 11:25:04
BC-1485 structure
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Common Name | BC-1485 | ||
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| CAS Number | 2035085-19-7 | Molecular Weight | 431.467 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H21N5O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BC-1485BC-1485 is a first-in-class, small molecule inhibitor of FIEL1 (Fibrosis-inducing E3 ligase 1) that exhibits potent activity toward disrupting FIEL1-directed PIAS4 ubiquitination; exhibits >100-fold activity in disrupting the FIEL1-PIAS4 interaction compared with BC-1480; dose-dependently increases PIAS4 protein levels, stabilize PIAS4 in cells; ameliorates fibrosis in murine models. |
| Name | BC-1485 |
|---|
| Description | BC-1485 is a first-in-class, small molecule inhibitor of FIEL1 (Fibrosis-inducing E3 ligase 1) that exhibits potent activity toward disrupting FIEL1-directed PIAS4 ubiquitination; exhibits >100-fold activity in disrupting the FIEL1-PIAS4 interaction compared with BC-1480; dose-dependently increases PIAS4 protein levels, stabilize PIAS4 in cells; ameliorates fibrosis in murine models. |
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| References | References 1. Lear T, et al. J Exp Med. 2016 May 30;213(6):1029-46. 2. Lear T, et al. Cytokine. 2016 Dec;88:193-195. View Related Products by Target E3 Ubiquitin Ligase |
| Molecular Formula | C19H21N5O5S |
|---|---|
| Molecular Weight | 431.467 |