27-Hydroxycholesterol
Modify Date: 2024-01-05 17:42:38
27-Hydroxycholesterol structure
|
Common Name | 27-Hydroxycholesterol | ||
|---|---|---|---|---|
| CAS Number | 20380-11-4 | Molecular Weight | 402.653 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 517.1±23.0 °C at 760 mmHg | |
| Molecular Formula | C27H46O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 215.6±17.2 °C | |
Use of 27-Hydroxycholesterol27-Hydroxycholesterol is a selective estrogen receptor modulator and an agonist of the liver X receptor. |
| Name | (25R)-cholest-5-ene-3β,26-diol |
|---|---|
| Synonym | More Synonyms |
| Description | 27-Hydroxycholesterol is a selective estrogen receptor modulator and an agonist of the liver X receptor. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | 27-Hydroxycholesterol is an endogenous selective estrogen receptor modulator that displays significant partial agonist activity in a variety of cellular models of estrogen receptor action. It positively regulates both gene transcription and cell proliferation in cellular models of breast cancer[1]. 27-Hydroxycholesterol, through estrogen receptor activation, triggers deleterious effect in prostate cancer cell lines. 27-Hydroxycholesterol significantly increases cell proliferation of LNCaP and PC3 cells and this effect can be attenuated by estrogen receptor inhibitors[2]. 27-Hydroxycholesterol is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. 27-Hydroxycholesterol also acts as an endogenous selective estrogen receptor modulator capable of increasing breast cancer growth and metastasis. 27-Hydroxycholesterol levels can be modulated by statins or direct inhibition of CYP27A1, thereby attenuating its pro-tumorigenic activities[3]. 27-hydroxylation of cholesterol is an important pathway for LXR activation in response to cholesterol overload[4]. |
| Cell Assay | Stock solutions of 27-Hydroxycholesterol are prepared in 100% ethanol and stored at −80°C. 27-Hydroxycholesterol stock solution is dissolved in appropriate volumes of media to prepare the working solutions of 1 μM. |
| Animal Admin | Proliferation assays are conducted on black 96 well plates using a commercial kit which quantifies cell number using DNA content and membrane integrity. LNCaP and PC3 cells are treated with 1 µM 27-Hydroxycholesterol for 48 hours[2]. |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 517.1±23.0 °C at 760 mmHg |
| Molecular Formula | C27H46O2 |
| Molecular Weight | 402.653 |
| Flash Point | 215.6±17.2 °C |
| Exact Mass | 402.349792 |
| PSA | 40.46000 |
| LogP | 7.84 |
| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
| Index of Refraction | 1.538 |
| Storage condition | 2-8℃ |
| Cholest-5-ene-3,26-diol, (3β,25R)- |
| (3β,25R)-Cholest-5-ene-3,26-diol |
| Cholest-5-ene-3β,26-diol, (25R)- |
| (25R)-cholest-5-ene-3beta,26-diol |
| 5,25R-Cholesten-3beta,26-diol |
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- China
- Product Name: 27-Hydroxycholesterol
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