L-Lysine-15N dihydrochloride

Modify Date: 2024-01-10 14:24:10

L-Lysine-15N dihydrochloride Structure
L-Lysine-15N dihydrochloride structure
Common Name L-Lysine-15N dihydrochloride
CAS Number 204451-50-3 Molecular Weight 220.10
Density N/A Boiling Point N/A
Molecular Formula C6H16Cl2N15NO2 Melting Point 200-206ºC (dec.)(lit.)
MSDS USA Flash Point N/A

 Use of L-Lysine-15N dihydrochloride


L-Lysine-15N (dihydrochloride) is a 15N-labeled Deruxtecan. Deruxtecan is an ADC drug-linker conjugate composed of a derivative of DX-8951 (DXd) and amaleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.

 Names

Name (2S)-6-amino-2-azanylhexanoic acid
Synonym More Synonyms

 L-Lysine-15N dihydrochloride Biological Activity

Description L-Lysine-15N (dihydrochloride) is a 15N-labeled Deruxtecan. Deruxtecan is an ADC drug-linker conjugate composed of a derivative of DX-8951 (DXd) and amaleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[75].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-239.

[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-239.

 Chemical & Physical Properties

Melting Point 200-206ºC (dec.)(lit.)
Molecular Formula C6H16Cl2N15NO2
Molecular Weight 220.10
Exact Mass 219.05600
PSA 89.34000
LogP 2.53190

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases 22-24/25
RIDADR NONH for all modes of transport

 Synonyms

L-Lysine-2-15N dihydrochloride