4-(3-hydroxypropyl)thiomorpholine 1,1-dioxide

Modify Date: 2024-04-03 12:53:32

4-(3-hydroxypropyl)thiomorpholine 1,1-dioxide Structure
4-(3-hydroxypropyl)thiomorpholine 1,1-dioxide structure
Common Name 4-(3-hydroxypropyl)thiomorpholine 1,1-dioxide
CAS Number 205194-33-8 Molecular Weight 193.26400
Density 1.241g/cm3 Boiling Point 418.25ºC at 760 mmHg
Molecular Formula C7H15NO3S Melting Point 195-196°C
MSDS N/A Flash Point 206.751ºC

 Names

Name 3-(1,1-dioxo-1,4-thiazinan-4-yl)propan-1-ol
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.241g/cm3
Boiling Point 418.25ºC at 760 mmHg
Melting Point 195-196°C
Molecular Formula C7H15NO3S
Molecular Weight 193.26400
Flash Point 206.751ºC
Exact Mass 193.07700
PSA 65.99000
LogP 0.11790
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.511

 MSDS


Section I.Chemical Product and Company Identification
Chemical Name 4-(3-Hydroxypropyl)thiomorpholine 1,1-Dioxide
Portland OR
4-Thiomorpholinepropanol, 1,1-dioxide (9CI)
Synonym
C7H15NO3S
Chemical Formula
CAS Number205194-33-8

Section II.Composition and Information on Ingredients
Chemical NameCAS Number Percent (%)TLV/PELToxicology Data
4-(3-Hydroxypropyl)thiomorpholine 1,1-Dioxide205194-33-8Min. 98.0 Not available.Not available.
(GC)

Section III. Hazards Identification
Acute Health EffectsNo specific information is available in our data base regarding the toxic effects of this material for humans. However,
exposure to any chemical should be kept to a minimum. Skin and eye contact may result in irritation. May be harmful if
inhaled or ingested. Always follow safe industrial hygiene practices and wear proper protective equipment when handling
this compound.
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
Chronic Health EffectsCARCINOGENIC EFFECTS : Not available.
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.

Section IV. First Aid Measures
Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
minutes. Get medical attention.
Skin ContactIn case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing
before reuse. Thoroughly clean shoes before reuse. Get medical attention.
InhalationIf the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or
waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
improve.
INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.
Ingestion
Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the
toxic material was ingested; the absence of such signs, however, is not conclusive.

Section V.Fire and Explosion Data
Not available.
FlammabilityMay be combustible at high temperature.Auto-Ignition
Flash PointsFlammable LimitsNot available.
Not available.
Combustion ProductsThese products are toxic carbon oxides (CO, CO2), nitrogen oxides (NO, NO2), sulfur oxides (SOx).
Fire Hazards
Not available.
Explosion HazardsRisks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
and Instructions
Consult with local fire authorities before attempting large scale fire-fighting operations.
Continued on Next Page
4-(3-Hydroxypropyl)thiomorpholine 1,1-Dioxide

Section VI.Accidental Release Measures
Spill CleanupUse a shovel to put the material into a convenient waste disposal container. Finish cleaning the spill by rinsing any
contaminated surfaces with copious amounts of water. Consult federal, state, and/or local authorities for assistance on
Instructions
disposal.

Section VII. Handling and Storage
Keep away from heat. Mechanical exhaust required. When not in use, tightly seal the container and store in a dry, cool
Handling and Storage
place. Avoid excessive heat and light. Do not breathe dust.
Information
Always store away from incompatible compounds such as oxidizing agents.

Section VIII. Exposure Controls/Personal Protection
Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal ProtectionSplash goggles. Lab coat. Dust respirator. Boots. Gloves. Suggested protective clothing might not be sufficient; consult
a specialist BEFORE handling this product. Be sure to use a MSHA/NIOSH approved respirator or equivalent.
Exposure LimitsNot available.

Section IX. Physical and Chemical Properties
Solid. (Light Reddish Yellow CrystallineSolubility
Physical state @ 20°CSoluble in Methanol.
Powder and Small Lumps.)
Not available.
Specific Gravity
Molecular Weight193.26Partition Coefficient
Not available.
Boiling PointNot available.Vapor PressureNot applicable.
73°C (163.4°F)Not available.
Melting PointVapor Density
Refractive IndexNot available.VolatilityNot available.
Critical TemperatureNot available.OdorNot available.
ViscosityNot available.TasteNot available.

Section X.Stability and Reactivity Data
Stability
This material is stable if stored under proper conditions. (See Section VII for instructions)
Conditions of InstabilityAvoid excessive heat and light.
Incompatibilities
Reactive with oxidizing agents.

Section XI. Toxicological Information
RTECS NumberNot available.
Eye Contact. Ingestion. Inhalation.
Routes of Exposure
Toxicity DataNot available.
CARCINOGENIC EFFECTS : Not available.
Chronic Toxic Effects
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.
Acute Toxic EffectsNo specific information is available in our data base regarding the toxic effects of this material for humans. However,
exposure to any chemical should be kept to a minimum. Skin and eye contact may result in irritation. May be harmful if
inhaled or ingested. Always follow safe industrial hygiene practices and wear proper protective equipment when handling
this compound.
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
Continued on Next Page
4-(3-Hydroxypropyl)thiomorpholine 1,1-Dioxide

Section XII.Ecological Information
EcotoxicityNot available.
Not available.
Environmental Fate

Section XIII. Disposal Considerations
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a
Waste Disposal
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
federal, state and local regulations when disposing of the substance.

Section XIV. Transport Information
DOT ClassificationNot a DOT controlled material (United States).
Not applicable.
PIN Number
Proper Shipping Name
Not applicable.
Packing Group (PG)Not applicable.
DOT Pictograms

Section XV. Other Regulatory Information and Pictograms
TSCA Chemical InventoryThis product is NOT on the EPA Toxic Substances Control Act (TSCA) inventory. The following notices are required by 40
CFR 720.36 (C) for those products not on the inventory list:
(EPA)
(i) These products are supplied solely for use in research and development by or under the supervision of a technically
qualified individual as defined in 40 CFR 720.0 et sec.
(ii) The health risks of these products have not been fully determined. Any information that is or becomes available will be
supplied on an MSDS sheet.
WHMIS ClassificationNot controlled under WHMIS (Canada).
(Canada)
EINECS Number (EEC)Not available.
EEC Risk StatementsNot available.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Risk Phrases R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases S26-S36/37/39
HS Code 2934999090

 Synthetic Route

~92%

4-(3-hydroxypropyl)thiomorpholine 1,1-dioxide Structure

4-(3-hydroxypro...

CAS#:205194-33-8

Literature: Zeneca Limited; Zeneca Pharma S.A. Patent: US6414148 B1, 2002 ; US 6414148 B1

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

4-Thiomorpholinepropanol,1,1-dioxide
N-(3-hydroxypropyl)-1,1-dioxotetrahydro-4H-1,4-thiazine
3-(1,1-dioxothiomorpholino)propan-1-ol
3-(1,1-dioxotetrahydro-4H-1,4-thiazin-4yl)propan-1-ol
MFCD03840678
4-(3-hydroxypropyl)-1,1-dioxotetrahydro-4H-thiazine
3-(1,1-Dioxothiomorpholino)-1-propanol
4-(3-Hydroxypropyl)thiomorpholine 1,1-Dioxide
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