Glutaminyl Cyclase Inhibitor 3

Modify Date: 2024-01-09 17:21:29

Glutaminyl Cyclase Inhibitor 3 Structure
Glutaminyl Cyclase Inhibitor 3 structure
Common Name Glutaminyl Cyclase Inhibitor 3
CAS Number 2092921-50-9 Molecular Weight 468.61
Density N/A Boiling Point N/A
Molecular Formula C24H32N6O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Glutaminyl Cyclase Inhibitor 3


Glutaminyl Cyclase Inhibitor 3 (compound 212 ), a designed anti-Alzheimer’s compound, is a potent human Glutaminyl Cyclase (GC) inhibitor, with an IC50 of 4.5 nM. Glutaminyl Cyclase-IN-1 (compound 212) significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions[1].

 Names

Name Glutaminyl Cyclase Inhibitor 3

 Glutaminyl Cyclase Inhibitor 3 Biological Activity

Description Glutaminyl Cyclase Inhibitor 3 (compound 212 ), a designed anti-Alzheimer’s compound, is a potent human Glutaminyl Cyclase (GC) inhibitor, with an IC50 of 4.5 nM. Glutaminyl Cyclase-IN-1 (compound 212) significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions[1].
Related Catalog
Target

IC50: 4.5 nM (hGC)[1].

References

[1]. Hoang VH, et al. Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer's Agents Based on Rational Design. J Med Chem. 2017 Mar 23;60(6):2573-2590.

 Chemical & Physical Properties

Molecular Formula C24H32N6O2S
Molecular Weight 468.61