FLT3-IN-5e
Modify Date: 2024-02-23 17:18:18
FLT3-IN-5e structure
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Common Name | FLT3-IN-5e | ||
|---|---|---|---|---|
| CAS Number | 2093038-25-4 | Molecular Weight | 305.385 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H19N5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of FLT3-IN-5eFLT3-IN-5e is a nove potent, selective FLT3 inhibitor with Kd of 3.6 nM, IC50 of <6 nM; has high potentcy against mutant FLT3 D835H, D835V, D835Y, ITD-D835V, ITD-F691L, K663Q, N841I, and R834Q (Kd=0.36-82 nM); shows weak (8-fold selectivity) activity for PDGFRB (28 nM) and the JAK1 JH2 domain (28 nM); possesses growth inhibitory potencies against MOLM13 FLT3-ITD and MOLM13 FLT3-ITD/D835Y cells. |
| Name | FLT3-IN-5e |
|---|
| Description | FLT3-IN-5e is a nove potent, selective FLT3 inhibitor with Kd of 3.6 nM, IC50 of <6 nM; has high potentcy against mutant FLT3 D835H, D835V, D835Y, ITD-D835V, ITD-F691L, K663Q, N841I, and R834Q (Kd=0.36-82 nM); shows weak (8-fold selectivity) activity for PDGFRB (28 nM) and the JAK1 JH2 domain (28 nM); possesses growth inhibitory potencies against MOLM13 FLT3-ITD and MOLM13 FLT3-ITD/D835Y cells. |
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| References | References 1. Jarusiewicz JA, et al. ACS Omega. 2017 May 31;2(5):1985-2009. View Related Products by Target FLT3 |
| Molecular Formula | C18H19N5 |
|---|---|
| Molecular Weight | 305.385 |