1-(2-PYRIMIDINYL) PIPERAZINE

Modify Date: 2024-01-02 18:20:15

1-(2-PYRIMIDINYL) PIPERAZINE structure	Common Name	1-(2-PYRIMIDINYL) PIPERAZINE
	CAS Number	20980-22-7	Molecular Weight	164.208
	Density	1.1±0.1 g/cm3	Boiling Point	328.0±52.0 °C at 760 mmHg
	Molecular Formula	C₈H₁₂N₄	Melting Point	32-34°C
	MSDS	Chinese USA	Flash Point	152.1±30.7 °C
	Symbol	GHS07	Signal Word	Warning

Use of 1-(2-PYRIMIDINYL) PIPERAZINE

2-(1-Piperazinyl)pyrimidine is the major metabolite of Tandospirone (HY-14558)[1].

Name	2-(1-Piperazinyl)pyrimidine
Synonym	More Synonyms

Description	2-(1-Piperazinyl)pyrimidine is the major metabolite of Tandospirone (HY-14558)[1].
Related Catalog	Research Areas >> Neurological Disease

Density	1.1±0.1 g/cm3
Boiling Point	328.0±52.0 °C at 760 mmHg
Melting Point	32-34°C
Molecular Formula	C₈H₁₂N₄
Molecular Weight	164.208
Flash Point	152.1±30.7 °C
Exact Mass	164.106201
PSA	41.05000
LogP	0.49
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.551
Storage condition	-20°C Freezer, Under Inert Atmosphere

1-(2-PYRIMIDINYL) PIPERAZINE MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV9702000

CHEMICAL NAME :: Pyrimidine, 2-(1-piperazinyl)-

CAS REGISTRY NUMBER :: 20980-22-7

BEILSTEIN REFERENCE NO. :: 0151178

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H12-N4

MOLECULAR WEIGHT :: 164.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 25,193,1991

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S24/25
RIDADR	UN3259
WGK Germany	3
RTECS	UV9702000
HS Code	2933990090

Precursor 8
CAS#:110-85-0 Piperazine CAS#:1722-12-9 chloropyrimidine CAS#:99931-83-6 1-Piperazinecar... CAS#:78069-54-2 2-piperazinopyr...
CAS#:109-12-6 2-Aminopyrimidine CAS#:334-22-5 3-BROMO-6,7-DIH... CAS#:780705-64-8 tert-Butyl 4-(p... CAS#:94021-22-4 1-(2-Pyrimidyl)...
DownStream 10
CAS#:33386-08-2 Buspirone hydro... CAS#:145208-86-2 2-(4-Methylpipe... CAS#:191487-40-8 1-(4-pyrimidin-... CAS#:36505-84-7 Buspirone
CAS#:30194-68-4 2-[4-(2-pyrimid... CAS#:87760-53-0 Tandospirone CAS#:83928-76-1 gepirone CAS#:99931-82-5 5-Bromo-2-piper...
CAS#:3605-01-4 Piribedil CAS#:88268-16-0 4-pyrimidin-2-y...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

The significant inhibition on CYP3A caused by radix Aconiti single herb is not observed in the Wutou decoction: The necessity of combination therapy of radix Aconiti.

J. Ethnopharmacol. 170 , 251-4, (2015)

Wutou (WT, Radix Aconiti), the mother root of Aconitum carmichaelii Debx., is a famous Chinese herb against rheumatoid arthritis. In Chinese clinics, PWT is often prepared as a decoction in combinatio...

The exposure of highly toxic aconitine does not significantly impact the activity and expression of cytochrome P450 3A in rats determined by a novel ultra performance liquid chromatography-tandem mass spectrometric method of a specific probe buspirone.

Food Chem. Toxicol. 51 , 396-403, (2013)

Aconitum species are widely used to treat rheumatism, cardiovascular diseases, and tumors in China and other Asian countries. The herbs are always used with drugs such as paclitaxel. Aconitine (AC) is...

Intravenous buspirone for the prevention of postoperative nausea and vomiting.

Eur. J. Clin. Pharmacol. 68(11) , 1465-72, (2012)

Buspirone, a partial 5HT(1A) agonist and D₂ and D₃ antagonist, has shown promising antiemetic efficacy when given parenterally in animal models, but its efficacy for the prevention of postoperative na...

2-piperazin-1-yl-pyrimidine

2-(Piperazin-1-yl)pyrimidin

2-(piperazin-1-yl)pyrimidine

EINECS 244-135-5

Pyrimidine, 2-(1-piperazinyl)-

1-pp

PMPRZ

RARECHEM AH CK 0195

1-(2-Pyrimidinyl)piperazine

2-piperazinopyrimidine

2,6-DICHLORO-4-[4-(4-METHYLPHENYL)-1,3-THIAZOL-2-YL]PYRIDINE

2-(1-Piperazinyl)pyrimidine

1-PYRIMIDYL PIPERAZINE

2-Piperazinylpyrimidine

1-(2-Pyrimidyl)piperazine

MFCD00040742

1-(2-PYRIMIDINYL) PIPERAZINE

Buspirone Impurity 1

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 1-(2-PYRIMIDINYL) PIPERAZINE
Price: Click To Check
Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 1-(2-PYRIMIDINYL) PIPERAZINE
Price: ￥88.0/5g ￥238.0/25g
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Dayang Chem (Hangzhou) Co., Ltd.
China
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Purity: 98.0%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU CHEM 2-(1-Piperazinyl)pyrimidine
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Purity: 99.0%
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