JC-171
Modify Date: 2024-09-13 19:33:16
JC-171 structure
|
Common Name | JC-171 | ||
|---|---|---|---|---|
| CAS Number | 2112809-98-8 | Molecular Weight | 384.831 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H17ClN2O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JC-171JC-171 is a selective NLRP3 inflammasome inhibitor that inhibits LPS/ATP-induced IL-1β release from macrophages with IC50 of 8.45 uM; interferes with NLRP3/ASC interaction induced by LPS/ATP stimulation both in vtiro and in vivo; delays the progression and reduces the severity of experimental autoimmune encephalomyelitis (EAE). |
| Name | JC-171 |
|---|
| Description | JC-171 is a selective NLRP3 inflammasome inhibitor that inhibits LPS/ATP-induced IL-1β release from macrophages with IC50 of 8.45 uM; interferes with NLRP3/ASC interaction induced by LPS/ATP stimulation both in vtiro and in vivo; delays the progression and reduces the severity of experimental autoimmune encephalomyelitis (EAE). |
|---|---|
| References | References 1. Guo C, et al. ACS Chem Neurosci. 2017 Jul 13. doi: 10.1021/acschemneuro.7b00124. View Related Products by Target NOD-like Receptor (NLR) |
| Molecular Formula | C16H17ClN2O5S |
|---|---|
| Molecular Weight | 384.831 |
| Hazard Codes | Xi |
|---|