Desmethyl-QCA276

Modify Date: 2024-01-19 13:20:38

Desmethyl-QCA276 Structure
Desmethyl-QCA276 structure
Common Name Desmethyl-QCA276
CAS Number 2126819-55-2 Molecular Weight 387.46
Density N/A Boiling Point N/A
Molecular Formula C21H17N5OS Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Desmethyl-QCA276


PROTAC BRD4-binding moiety 4 (compound 22) is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM. PROTAC BRD4-binding moiety 4 is a BET ligand for PROTAC which is an extremely potent BET degrader[1].

 Names

Name PROTAC BRD4-binding moiety 4

 Desmethyl-QCA276 Biological Activity

Description PROTAC BRD4-binding moiety 4 (compound 22) is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM. PROTAC BRD4-binding moiety 4 is a BET ligand for PROTAC which is an extremely potent BET degrader[1].
Related Catalog
References

[1]. Qin C, et al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem. 2018 Aug 9;61(15):6685-6704.

 Chemical & Physical Properties

Molecular Formula C21H17N5OS
Molecular Weight 387.46
Storage condition 2-8°C
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