N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN

Modify Date: 2024-02-07 18:08:44

N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN Structure
N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN structure
Common Name N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN
CAS Number 216758-20-2 Molecular Weight 397.549
Density 1.2±0.1 g/cm3 Boiling Point 569.9±50.0 °C at 760 mmHg
Molecular Formula C22H39NO5 Melting Point N/A
MSDS N/A Flash Point 298.4±30.1 °C

 Use of N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN


AMP-Deoxynojirimycin (AMP-DNM) is a potent ceramide glucosyltransferase and GCase 2 inhibitor. AMP-Deoxynojirimycin also is a GlcCer biosynthesis inhibitor[1][2].

 Names

Name AMP-Deoxynojirimycin
Synonym More Synonyms

  Biological Activity

Description AMP-Deoxynojirimycin (AMP-DNM) is a potent ceramide glucosyltransferase and GCase 2 inhibitor. AMP-Deoxynojirimycin also is a GlcCer biosynthesis inhibitor[1][2].
Related Catalog
In Vitro AMP-Deoxynojirimycin (10 μM) significantly blocks the leucine and C17ISO-induced P70S6K phosphorylation in 3T3-L1 cells[1].
References

[1]. Zhu M, et al. Monomethyl branched-chain fatty acid mediates amino acid sensing upstream of mTORC1. Dev Cell. 2021 Oct 11;56(19):2692-2702.e5.  

[2]. Bae EJ, et al. Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and α-synuclein aggregation. Exp Mol Med. 2015 Mar 27;47(3):e153.  

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 569.9±50.0 °C at 760 mmHg
Molecular Formula C22H39NO5
Molecular Weight 397.549
Flash Point 298.4±30.1 °C
Exact Mass 397.282837
PSA 93.39000
LogP 3.04
Vapour Pressure 0.0±3.6 mmHg at 25°C
Index of Refraction 1.570

 Synonyms

(2R,3R,4R,5S)-1-{5-[(3s,5s,7s)-Adamantan-1-ylmethoxy]pentyl}-2-(hydroxymethyl)-3,4,5-piperidinetriol
(2R,3R,4R,5S)-1-[5-(Adamantan-1-ylmethoxy)pentyl]-2-(hydroxymethyl)-3,4,5-piperidinetriol
3,4,5-Piperidinetriol, 2-(hydroxymethyl)-1-[5-(tricyclo[3.3.1.1]dec-1-ylmethoxy)pentyl]-, (2R,3R,4R,5S)-
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