M-525

Modify Date: 2024-01-04 11:08:11

M-525 Structure
M-525 structure
Common Name M-525
CAS Number 2173582-08-4 Molecular Weight 734.932
Density N/A Boiling Point N/A
Molecular Formula C39H51FN6O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of M-525


M-525 is a first-in-class, highly potent, irreversible small-molecule inhibitor of the menin-MLL interaction with binding IC50 of 3.3 nM in FP assays; inhibits MV4;11 (MLL fusion) and HL60 (No MLL fusion) cell growth with IC50 of 2.7 and 2,000 nM, respectively; significantly down-regulates the expression of MEIS1, HOXA9 and HOXA11 genes in a dosedependent anner at ow nanomolar concentrations, also effectively suppresses the expression of MEIS1 and HOX genes in the MOLM-13 cell line at 3 nM.

 Names

Name M-525

 M-525 Biological Activity

Description M-525 is a first-in-class, highly potent, irreversible small-molecule inhibitor of the menin-MLL interaction with binding IC50 of 3.3 nM in FP assays; inhibits MV4;11 (MLL fusion) and HL60 (No MLL fusion) cell growth with IC50 of 2.7 and 2,000 nM, respectively; significantly down-regulates the expression of MEIS1, HOXA9 and HOXA11 genes in a dosedependent anner at ow nanomolar concentrations, also effectively suppresses the expression of MEIS1 and HOX genes in the MOLM-13 cell line at 3 nM.
References References 1. Xu S, et al. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1601-1605. View Related Products by Target Histone Methyltransferase (HMTase)

 Chemical & Physical Properties

Molecular Formula C39H51FN6O5S
Molecular Weight 734.932
Top Suppliers:I want be here



Get all suppliers and price by the below link:

M-525 suppliers

M-525 price