Daunomycinone

Modify Date: 2024-01-09 16:58:29

Daunomycinone structure	Common Name	Daunomycinone
	CAS Number	21794-55-8	Molecular Weight	398.36
	Density	1.6±0.1 g/cm3	Boiling Point	677.4±55.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₁₈O₈	Melting Point	208-210°C
	MSDS	N/A	Flash Point	243.4±25.0 °C

Use of Daunomycinone

Daunomycinone (NSC-109351) is a metabolite of daunomycin. Daunomycin is an antibiotic with antitumor activity[1][2].

Name	Daunomycinone
Synonym	More Synonyms

Description	Daunomycinone (NSC-109351) is a metabolite of daunomycin. Daunomycin is an antibiotic with antitumor activity[1][2].
Related Catalog	Research Areas >> Cancer
References	[1]. Herman EH, et al. Modification of some of the toxic effects of daunomycin (NSC-82,151) by pretreatment with the antineoplastic agent ICRF 159 (NSC-129,943). Toxicol Appl Pharmacol. 1974 Mar;27(3):517-26. [2]. Tan C, et al. Daunomycin, an antitumor antibiotic, in the treatment of neoplastic disease. Clinical evaluation with special reference to childhood leukemia. Cancer. 1967 Mar;20(3):333-53.

Description

Daunomycinone (NSC-109351) is a metabolite of daunomycin. Daunomycin is an antibiotic with antitumor activity[1][2].

Related Catalog

Research Areas >> Cancer

References

[1]. Herman EH, et al. Modification of some of the toxic effects of daunomycin (NSC-82,151) by pretreatment with the antineoplastic agent ICRF 159 (NSC-129,943). Toxicol Appl Pharmacol. 1974 Mar;27(3):517-26.

[2]. Tan C, et al. Daunomycin, an antitumor antibiotic, in the treatment of neoplastic disease. Clinical evaluation with special reference to childhood leukemia. Cancer. 1967 Mar;20(3):333-53.

Density	1.6±0.1 g/cm3
Boiling Point	677.4±55.0 °C at 760 mmHg
Melting Point	208-210°C
Molecular Formula	C₂₁H₁₈O₈
Molecular Weight	398.36
Flash Point	243.4±25.0 °C
Exact Mass	398.100159
PSA	141.36000
LogP	2.93
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.713
Storage condition	-20°C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QI9295500

CHEMICAL NAME :: 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1 -methoxy-, (8S, 10S)-

CAS REGISTRY NUMBER :: 21794-55-8

LAST UPDATED :: 199409

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H18-O8

MOLECULAR WEIGHT :: 398.39

WISWESSER LINE NOTATION :: L E6 C666 BV MVT&&&J DQ FQ HV1 HQ KQ RO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 2 umol/L

REFERENCE :: CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1939- Volume(issue)/page/year: 68,115,1978

RIDADR	UN 2811 6.1 / PGIII

Semiquinone free radical formation by daunorubicin aglycone incorporated into the cellular membranes of intact Chinese hamster ovary cells.

Free Radic. Res. 24(1) , 9-18, (1996)

The production of semiquinone free radicals has been measured by electron paramagnetic resonance spectroscopy (EPR) in Chinese hamster ovary cells in which 7-hydroxy daunorubicin aglycone had been inc...

Biotransformation of aklanonic acid by blocked mutants of anthracycline-producing strains of Streptomyces galilaeus and Streptomyces peucetius.

J. Basic Microbiol. 26(4) , 249-55, (1986)

Aklanonic acid is an anthracyclinone-related pigment that was found to be an intermediate at an early stage of the biosynthesis of daunomycinone glycosides by Streptomyces griseus. We now isolated ant...

Synthesis and biological activity of (7S)-O-epoxyalkyl derivatives of daunomycinone.

J. Antibiot. 38(12) , 1714-8, (1985)

Synthesis and antibacterial activity of a number of 7-O-epoxyalkyl derivatives of daunomycinone prepared from 7-O-alkenyl derivatives of daunomycinone are described along with their inhibitory effect ...

5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1-methoxy-, (8S,10S)-

(8S,10S)-8-Acetyl-6,8,10,11-tetrahydroxy-1-methoxy-7,8,9,10-tetrahydro-5,12-tetracenedione

daunomycinone

5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1-methoxy-, (8S-cis)-

(8S,10S)-8-Acetyl-6,8,10,11-tetrahydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione

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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5,12-Naphthacenedione,8-acetyl-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1-methoxy-, (8S,10S)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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