KB-141
Modify Date: 2024-07-25 13:06:18
KB-141 structure
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Common Name | KB-141 | ||
|---|---|---|---|---|
| CAS Number | 219691-94-8 | Molecular Weight | 355.212 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 464.7±45.0 °C at 760 mmHg | |
| Molecular Formula | C17H16Cl2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 234.9±28.7 °C | |
Use of KB-141KB-141 (KB141) is a potent, selective thyroid hormone receptor TRβ agonist (IC50=1.1 nM), binds to hTRβ with a 14-fold higher affinity than to hTRα; selectively reduces plasma cholesterol levels, also increases whole body oxygen consumption (MVO2) in both mice and rats. |
| Name | KB-141 |
|---|---|
| Synonym | More Synonyms |
| Description | KB-141 (KB141) is a potent, selective thyroid hormone receptor TRβ agonist (IC50=1.1 nM), binds to hTRβ with a 14-fold higher affinity than to hTRα; selectively reduces plasma cholesterol levels, also increases whole body oxygen consumption (MVO2) in both mice and rats. |
|---|---|
| References | References 1. Grover GJ, et al. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10067-72. 2. Johansson L, et al. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10297-302. 3. Grover GJ, et al. Cardiovasc Drug Rev. 2005 Summer;23(2):133-48. Review. 4. Ye L, et al. J Med Chem. 2003 Apr 24;46(9):1580-8. View Related Products by Target Thyroid Hormone Receptor (THR) |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 464.7±45.0 °C at 760 mmHg |
| Molecular Formula | C17H16Cl2O4 |
| Molecular Weight | 355.212 |
| Flash Point | 234.9±28.7 °C |
| Exact Mass | 354.042572 |
| LogP | 4.75 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.606 |
| Benzeneacetic acid, 3,5-dichloro-4-[4-hydroxy-3-(1-methylethyl)phenoxy]- |
| KB-141 |
| 3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)phenylacetic acid |
| [3,5-Dichloro-4-(4-hydroxy-3-isopropylphenoxy)phenyl]acetic acid |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: KB-141
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: KB-141
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: KB-141
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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