T-3861174
Modify Date: 2023-01-17 16:27:21
T-3861174 structure
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Common Name | T-3861174 | ||
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| CAS Number | 2209057-94-1 | Molecular Weight | 472.524 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H25FN6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of T-3861174T-3861174 is a novel small molecule prolyl tRNA synthetase (PRS) with binding IC50 of 2.3 nM; induces cell death in several tumor cell lines including SK-MEL-2 (IC50=0.1 uM) without complete suppression of translation, T-3861174-induced cell death was caused by activation of the GCN2-ATF4 pathway; exhibits significant tumor growth inhibition inSK-MEL-2, G-361, and HT-1080 xenograft models without severe body weight losses. |
| Name | T-3861174 |
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| Description | T-3861174 is a novel small molecule prolyl tRNA synthetase (PRS) with binding IC50 of 2.3 nM; induces cell death in several tumor cell lines including SK-MEL-2 (IC50=0.1 uM) without complete suppression of translation, T-3861174-induced cell death was caused by activation of the GCN2-ATF4 pathway; exhibits significant tumor growth inhibition inSK-MEL-2, G-361, and HT-1080 xenograft models without severe body weight losses. |
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| References | References 1. Arita T, et al. Biochem Biophys Res Commun. 2017 Jul 8;488(4):648-654. View Related Products by Target Other Targets |
| Molecular Formula | C26H25FN6O2 |
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| Molecular Weight | 472.524 |