Seriniquinone
Modify Date: 2024-01-17 19:27:57
Seriniquinone structure
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Common Name | Seriniquinone | ||
|---|---|---|---|---|
| CAS Number | 22200-69-7 | Molecular Weight | 344.340 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 612.3±54.0 °C at 760 mmHg | |
| Molecular Formula | C20H8O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 324.1±31.2 °C | |
Use of SeriniquinoneA melanoma-selective anticancer agent (IC50=30 nM, Malme-3M cell line), induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin; demonstrates potent activity over a select set of tumor cell lines with particular selectivity toward melanoma cell lines; increases the cleavage of caspases 3, 7, and 9 and PARP in HCT-116 cells; causes an increasing level of DCD expression directly correlated with cell line selectivity, |
| Name | seriniquinone |
|---|---|
| Synonym | More Synonyms |
| Description | A melanoma-selective anticancer agent (IC50=30 nM, Malme-3M cell line), induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin; demonstrates potent activity over a select set of tumor cell lines with particular selectivity toward melanoma cell lines; increases the cleavage of caspases 3, 7, and 9 and PARP in HCT-116 cells; causes an increasing level of DCD expression directly correlated with cell line selectivity, |
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| References | References 1. Trzoss L, et al. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14687-92. 2. Matsuoka M, et al. J Heterocycl Chem. 1991;28(5):1445–1447. View Related Products by Target Other Targets |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 612.3±54.0 °C at 760 mmHg |
| Molecular Formula | C20H8O4S |
| Molecular Weight | 344.340 |
| Flash Point | 324.1±31.2 °C |
| Exact Mass | 344.014343 |
| LogP | 4.62 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.757 |
| seriniquinone |
| Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone |