ZL0420
Modify Date: 2024-04-06 13:09:21
ZL0420 structure
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Common Name | ZL0420 | ||
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| CAS Number | 2229039-45-4 | Molecular Weight | 296.324 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 645.9±55.0 °C at 760 mmHg | |
| Molecular Formula | C16H16N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 344.4±31.5 °C | |
Use of ZL0420ZL0420 is a potent, highly selective BRD4 inhibitor with IC50 of 27 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively; displays selectivity over BRD2, BRD3, and BRDT (BRD2-BD1 and BRD2-BD2, IC50=803 and 1736 nM); disrupts the BRD4 complex with Pol II and histones, inhibits poly(I:C)-induced expression of innate immune genes IL6 and CIG5 in human small airway epithelial cells (hSAECs) (IC50=0.54 and 0.51 uM); blocks Poly(I:C)-induced inflammation and neutrophilia in vivo. |
| Name | 6-[(E)-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-3,4-dihydro-2(1H)-quinolinone |
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| Synonym | More Synonyms |
| Description | ZL0420 is a potent, highly selective BRD4 inhibitor with IC50 of 27 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively; displays selectivity over BRD2, BRD3, and BRDT (BRD2-BD1 and BRD2-BD2, IC50=803 and 1736 nM); disrupts the BRD4 complex with Pol II and histones, inhibits poly(I:C)-induced expression of innate immune genes IL6 and CIG5 in human small airway epithelial cells (hSAECs) (IC50=0.54 and 0.51 uM); blocks Poly(I:C)-induced inflammation and neutrophilia in vivo. |
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| References | References 1. Tian B, et al. Cell Rep. 2018 Apr 24;23(4):1138-1151. 2. Liu Z, et al. Eur J Med Chem 2018 May 10;151:450-461. View Related Products by Target Bromodomain |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 645.9±55.0 °C at 760 mmHg |
| Molecular Formula | C16H16N4O2 |
| Molecular Weight | 296.324 |
| Flash Point | 344.4±31.5 °C |
| Exact Mass | 296.127319 |
| LogP | 2.19 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.704 |
| Storage condition | -20℃ |
| 6-[(E)-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-3,4-dihydro-2(1H)-quinolinone |
| 2(1H)-Quinolinone, 6-[(E)-2-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-3,4-dihydro- |