KDOAM-25
Modify Date: 2024-01-08 13:41:56
KDOAM-25 structure
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Common Name | KDOAM-25 | ||
|---|---|---|---|---|
| CAS Number | 2230731-99-2 | Molecular Weight | 307.398 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H25N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of KDOAM-25KDOAM-25 (KDM5 inhibitor KDOAM 25) is a potent, selective KDM5 sub-family(JARID1) inhibitor with biochemical IC50 of 71/19/69/69 nM for KDM5A/B/C/D, respectively; weakly inhibits KDM4C/KDM2B (IC50=4.8/4.4 uM) and good selectivity over other demethylases; most potently inhibits KDM5B (IC50=50 uM) and increases H3K4me3 levels in Hela cells; increases global H3K4 methylation, causes G1 cell-cycle arrest and impairs cell proliferation in multiple myeloma MM1S cells. |
| Name | KDOAM-25 |
|---|
| Description | KDOAM-25 (KDM5 inhibitor KDOAM 25) is a potent, selective KDM5 sub-family(JARID1) inhibitor with biochemical IC50 of 71/19/69/69 nM for KDM5A/B/C/D, respectively; weakly inhibits KDM4C/KDM2B (IC50=4.8/4.4 uM) and good selectivity over other demethylases; most potently inhibits KDM5B (IC50=50 uM) and increases H3K4me3 levels in Hela cells; increases global H3K4 methylation, causes G1 cell-cycle arrest and impairs cell proliferation in multiple myeloma MM1S cells. |
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| References | References 1. Tumber A, et al. Cell Chem Biol. 2017 Mar 16;24(3):371-380. View Related Products by Target Histone Demethylase |
| Molecular Formula | C15H25N5O2 |
|---|---|
| Molecular Weight | 307.398 |
| Storage condition | -20°C |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: KDOAM-25
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: KDOAM-25
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: KDOAM-25
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
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