Diacetolol
Diacetolol structure
|
Common Name | Diacetolol | ||
|---|---|---|---|---|
| CAS Number | 22568-64-5 | Molecular Weight | 308.37 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 548.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C16H24N2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 285.7±30.1 °C | |
Use of DiacetololDiacetolol is an active metabolite of the beta-adrenoceptor blocking agent Acebutolol (HY-17497)[1]. |
| Name | rac Diacetolol |
|---|---|
| Synonym | More Synonyms |
| Description | Diacetolol is an active metabolite of the beta-adrenoceptor blocking agent Acebutolol (HY-17497)[1]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 548.8±50.0 °C at 760 mmHg |
| Molecular Formula | C16H24N2O4 |
| Molecular Weight | 308.37 |
| Flash Point | 285.7±30.1 °C |
| Exact Mass | 308.173615 |
| PSA | 91.15000 |
| LogP | 0.89 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.551 |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| RIDADR | NONH for all modes of transport |
|---|---|
| HS Code | 2924299090 |
| HS Code | 2924299090 |
|---|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
|
Using supported liquid extraction together with cellobiohydrolase chiral stationary phases-based liquid chromatography with tandem mass spectrometry for enantioselective determination of acebutolol and its active metabolite diacetolol in spiked human plasma.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(3) , 173-80, (2009) A high through-put, sensitive, and enantioselective LC-MS/MS-based bioanalytical method was developed and validated for the simultaneous determination of individual acebutolol (AC) and its active meta... |
|
|
Acebutolol: a review of its pharmacology, pharmacokinetics, clinical uses, and adverse effects.
Pharmacotherapy 6(2) , 45-63, (1986) Acebutolol is a new hydrophilic, cardioselective beta-adrenergic-blocking agent that possesses partial agonist and membrane-stabilizing activities. In the treatment of mild to moderate essential hyper... |
|
|
Preliminary study of the disposition in man of acebutolol and its metabolite, diacetolol, using a new stereoselective hplc method.
J. Pharm. Pharmacol. 36(4) , 276-7, (1984) A new stereospecific hplc method that is capable of simultaneously quantitating the S-(-)- and R-(+)-enantiomers of acebutolol and its major metabolite, diacetolol, in plasma and urine, is described. ... |
| N-{3-Acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}acetamide |
| N-{3-Acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}acetami de |
| Acebutolol impurity B |
| N-{3-acetyl-4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}acetamide |
| N-{3-Acetyl-4-{(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy}phenyl}acetamide |
| Acetamide, N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]- |
| Diacetolol |
| EINECS 245-088-3 |