(R)-(+)-4-Hydroxy-2-pyrrolidinone

Modify Date: 2024-01-02 11:38:18

(R)-(+)-4-Hydroxy-2-pyrrolidinone Structure
(R)-(+)-4-Hydroxy-2-pyrrolidinone structure
Common Name (R)-(+)-4-Hydroxy-2-pyrrolidinone
CAS Number 22677-21-0 Molecular Weight 101.104
Density 1.3±0.1 g/cm3 Boiling Point 363.6±35.0 °C at 760 mmHg
Molecular Formula C4H7NO2 Melting Point 156-160ºC
MSDS Chinese USA Flash Point 173.7±25.9 °C
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name (4R)-4-hydroxypyrrolidin-2-one
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 363.6±35.0 °C at 760 mmHg
Melting Point 156-160ºC
Molecular Formula C4H7NO2
Molecular Weight 101.104
Flash Point 173.7±25.9 °C
Exact Mass 101.047676
PSA 49.33000
LogP -2.55
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.513

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2933790090

 Synthetic Route

~%

(R)-(+)-4-Hydroxy-2-pyrrolidinone Structure

(R)-(+)-4-Hydro...

CAS#:22677-21-0

Literature: US6031113 A1, ;

~51%

(R)-(+)-4-Hydroxy-2-pyrrolidinone Structure

(R)-(+)-4-Hydro...

CAS#:22677-21-0

Literature: Aube; Wang; Ghosh; Langhans Synthetic Communications, 1991 , vol. 21, # 5 p. 693 - 701

~%

(R)-(+)-4-Hydroxy-2-pyrrolidinone Structure

(R)-(+)-4-Hydro...

CAS#:22677-21-0

Literature: Journal of Chemical Research, Miniprint, , # 11 p. 2701 - 2711

~80%

(R)-(+)-4-Hydroxy-2-pyrrolidinone Structure

(R)-(+)-4-Hydro...

CAS#:22677-21-0

Literature: Pellegata, R.; Dosi, I.; Villa, M.; Lesma, G.; Palmisano, G. Tetrahedron, 1985 , vol. 41, # 23 p. 5607 - 5614

 Precursor & DownStream

Precursor  1

DownStream  1

 Customs

HS Code 2933790090
Summary 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

 Articles1

More Articles
Phase diagram of (R)- and (S)-4-hydroxy-2-pyrrolidone mixtures: a new case of a conglomerate-forming system.

J. Pharm. Sci. 82(7) , 758-60, (1993)

The phase diagram of (R)- and (S)-4-hydroxy-2-pyrrolidone presents a conglomerate in the racemic mixture. The enthalpy of melting extrapolated by the Schröder-van Laar-Le Chatelier equation [change in...

 Synonyms

(R)-(+)-4-Hydroxy-2-pyrrolidinone
(4R)-4-hydroxypyrrolidin-2-one
4(R)-hydroxy-2-pyrrolidinone
(R)-4-Hydroxypyrrolidin-2-one
(4R)-4-Hydroxypyrrolidin-2-on
(R)-4-Hydroxy-2-pyrrolidone
RHPD
(R)-4-HYDROXY-2-PYRROLIDINONE
MFCD00273364
(4S)-4-hydroxypyrrolidin-2-one
(4R)-4-hydroxy-2-pyrrolidone
(4S)-4-Hydroxy-2-pyrrolidinone
(S)-4-Hydroxy-pyrrolidine-2-one
(S)-4-Hydroxy-2-pyrrolidinone
(4R)-4-Hydroxy-2-pyrrolidinone
2-Pyrrolidinone, 4-hydroxy-, (4S)-
2-Pyrrolidinone, 4-hydroxy-, (4R)-
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