Aminocandin

Modify Date: 2024-01-10 16:40:37

Aminocandin structure	Common Name	Aminocandin
	CAS Number	227472-48-2	Molecular Weight	1102.28
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅₆H₇₉N₉O₁₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Aminocandin

Aminocandin (HMR 3270) is water-soluble antifungal drug of the echinocandin class with excellent activity against Aspergillus and Candida spp.[1].

Name	Aminocandin

Description	Aminocandin (HMR 3270) is water-soluble antifungal drug of the echinocandin class with excellent activity against Aspergillus and Candida spp.[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
Target	Fungal[1]
In Vitro	Aminocandin (HMR 3270) inhibits Fluconazole (HY-B0101)-resistant C. albicans strain MRL 648 with an MIC of 0.25 mg/L[2]. Aminocandin shows half-life of 48-58 h[2].
In Vivo	Aminocandin (1-10 mg/kg; i.v. or i.p.; once daily for 11 days) is highly effective in reducing mortality and organ burden in disseminated infection caused by ITC-susceptible and -resistant A. fumigatus in mice[1]. Aminocandin (5 and 10 mg/kg; i.v.; once or twice a week for 4 weeks) is an effective addition to the arsenal of antifungal compounds for the treatment of candidiasis caused by Fluconazole (HY-B0101)-resistant C. albicans in immunocompetent mice[2]. Animal Model: Immunosuppressed male CD1 mice, Aspergillus fumigatus infection model[1] Dosage: 10, 5, 1 and 0.25 mg/kg (IV) or 1 mg/kg (IP) Administration: IV or IP, once daily for 11 days Result: Increased the survival rate, 5 mg/kg i.v. yielded 100% survival following infection with AF91.

Molecular Formula	C₅₆H₇₉N₉O₁₄
Molecular Weight	1102.28