RIPK1-IN-7
Modify Date: 2024-02-01 23:40:37
RIPK1-IN-7 structure
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Common Name | RIPK1-IN-7 | ||
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| CAS Number | 2300982-44-7 | Molecular Weight | 481.47 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H22F3N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RIPK1-IN-7RIPK1-IN-7 is a potent and selective receptor-interacting protein kinase 1 (RIPK1) inhibitor with a Kd of 4 nM and an enzymatic IC50 of 11 nM. RIPK1-IN-7 exhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model[1]. |
| Name | RIPK1-IN-7 |
|---|
| Description | RIPK1-IN-7 is a potent and selective receptor-interacting protein kinase 1 (RIPK1) inhibitor with a Kd of 4 nM and an enzymatic IC50 of 11 nM. RIPK1-IN-7 exhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model[1]. |
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| Related Catalog | |
| Target |
Kd: 4 nM (Receptor-interacting protein kinase 1)[1] IC50: 11 nM (Receptor-interacting protein kinase 1)[1] |
| In Vitro | RIPK1-IN-7 shows potent cell protection effect in the TSZ-induced HT29 cell necroptosis model with an EC50 of 2nM[1]. RIPK1-IN-7 displays considerable activity against several other kinases, such as Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC50s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively[1]. |
| References |
| Molecular Formula | C25H22F3N5O2 |
|---|---|
| Molecular Weight | 481.47 |
| Storage condition | 2-8℃ |