IMP-1710
Modify Date: 2024-01-13 13:11:02
IMP-1710 structure
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Common Name | IMP-1710 | ||
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| CAS Number | 2383117-96-0 | Molecular Weight | 381.439 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H19N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IMP-1710IMP-1710 (IMP1710) is a potent, selective, covalent UCHL1 inhibitor with IC50 of 38 nM.IMP-1710 demonstrated exquisite selectivity in a cross-screening against 20 DUBs.IMP-1710 can profile activity of endogenous UCHL1 with excellent selectivity in cell types including endothelial cells (EA.hy926) and adenocarcinoma human alveolar basal epithelial cells (A549).IMP-1710 demonstrated >50% fibroblast–myofibroblast transition (FMT) inhibition (IC50=740 nM) in idiopathic pulmonary fibrosis (IPF), as well as αSMA inhibition.IMP-1710 is a powerful and selective probe to explore UCHL1 activity with potential application to substrate identification, mode of action studies, and cellular target profiling. |
| Name | IMP-1710 |
|---|
| Description | IMP-1710 (IMP1710) is a potent, selective, covalent UCHL1 inhibitor with IC50 of 38 nM.IMP-1710 demonstrated exquisite selectivity in a cross-screening against 20 DUBs.IMP-1710 can profile activity of endogenous UCHL1 with excellent selectivity in cell types including endothelial cells (EA.hy926) and adenocarcinoma human alveolar basal epithelial cells (A549).IMP-1710 demonstrated >50% fibroblast–myofibroblast transition (FMT) inhibition (IC50=740 nM) in idiopathic pulmonary fibrosis (IPF), as well as αSMA inhibition.IMP-1710 is a powerful and selective probe to explore UCHL1 activity with potential application to substrate identification, mode of action studies, and cellular target profiling. |
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| References | 1. Nattawadee Panyain, et al. J Am Chem Soc. 2020 Jul 15;142(28):12020-12026. |
| Molecular Formula | C23H19N5O |
|---|---|
| Molecular Weight | 381.439 |