DZD1516

Modify Date: 2024-01-04 09:53:24

DZD1516 Structure
DZD1516 structure
Common Name DZD1516
CAS Number 2387570-00-3 Molecular Weight 547.56
Density N/A Boiling Point N/A
Molecular Formula C28H27F2N7O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DZD1516


DZD1516 is a potent and selective HER2 inhibitor (IC50=0.56 nM) with good blood-brain permeability. DZD1516 exhibits antitumor activity in CNS and subcutaneous xenograft mouse models[1].

 Names

Name DZD1516

 DZD1516 Biological Activity

Description DZD1516 is a potent and selective HER2 inhibitor (IC50=0.56 nM) with good blood-brain permeability. DZD1516 exhibits antitumor activity in CNS and subcutaneous xenograft mouse models[1].
Related Catalog
Target

HER2

References

[1]. Zhang J, et al. Preclinical and clinical activity of DZD1516, a full blood-brain barrier-penetrant, highly selective HER2 inhibitor. Breast Cancer Res. 2023 Jul 6;25(1):81.  

 Chemical & Physical Properties

Molecular Formula C28H27F2N7O3
Molecular Weight 547.56