CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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SG1600500
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CHEMICAL NAME :
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Phenazinium, 3-amino-7-(dimethylamino)-5-phenyl-, chloride
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CAS REGISTRY NUMBER :
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2390-56-9
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LAST UPDATED :
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199701
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DATA ITEMS CITED :
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5
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MOLECULAR FORMULA :
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C20-H19-N4.Cl
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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46 mg/kg/4D-I
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TOXIC EFFECTS :
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Related to Chronic Data - death
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REFERENCE :
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BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 7,494,1952
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Primate - monkey
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DOSE/DURATION :
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60 mg/kg/9D-I
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TOXIC EFFECTS :
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Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death
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REFERENCE :
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BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 7,494,1952
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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600 mg/kg/4D-I
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Behavioral - food intake (animal) Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
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REFERENCE :
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BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 7,494,1952
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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50 mg/kg/10D-I
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Behavioral - food intake (animal) Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
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REFERENCE :
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BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 7,494,1952
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