β-Muricholic Acid
Modify Date: 2024-01-18 17:08:04
β-Muricholic Acid structure
|
Common Name | β-Muricholic Acid | ||
|---|---|---|---|---|
| CAS Number | 2393-59-1 | Molecular Weight | 408.57100 | |
| Density | 1.184g/cm3 | Boiling Point | 565.7ºC at 760mmHg | |
| Molecular Formula | C24H40O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 310ºC | |
Use of β-Muricholic Acidβ-Muricholic acid is a potent and orally active biliary cholesterol-desaturating agent. β-Muricholic acid prevents cholesterol gallstones. β-Muricholic acid inhibits lipid accumulation. β-Muricholic acid has the potential for the research of nonalcoholic fatty liver disease (NAFLD)[1][2]. |
| Name | (3α,5β,6β,7β)-3,6,7-Trihydroxycholan-24-oic acid |
|---|---|
| Synonym | More Synonyms |
| Description | β-Muricholic acid is a potent and orally active biliary cholesterol-desaturating agent. β-Muricholic acid prevents cholesterol gallstones. β-Muricholic acid inhibits lipid accumulation. β-Muricholic acid has the potential for the research of nonalcoholic fatty liver disease (NAFLD)[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | β-Muricholic acid (100µM; 48 h) 抑制小鼠原代肝细胞中的脂质积累[1]。 |
| In Vivo | β-Muricholic acid (用 0.5% β-鼠胆酸喂食 8 周) 可预防小鼠的饮食诱导或实验性胆固醇胆结石[2]。 Animal Model: 6-8 weeks, Male C57L/J mice (with a lithogenic diet (2% cholesterol and 0.5% cholic acid))[2] Dosage: 0.5% β-muricholic acid Administration: Fed chow with 0.5% β-muricholic acid for 8 weeks Result: Decreased gallstone prevalence to 20% through significantly reducing biliary secretion rate, saturation index, and intestinal absorption of cholesterol, as well as inducing phase boundary shift and an enlarged Region E that prevented the transition of cholesterol from its liquid crystalline phase to solid crystals and stones. |
| References |
| Density | 1.184g/cm3 |
|---|---|
| Boiling Point | 565.7ºC at 760mmHg |
| Molecular Formula | C24H40O5 |
| Molecular Weight | 408.57100 |
| Flash Point | 310ºC |
| Exact Mass | 408.28800 |
| PSA | 97.99000 |
| LogP | 3.44870 |
| Vapour Pressure | 3.75E-15mmHg at 25°C |
| Index of Refraction | 1.558 |
| 2-Cyan-3-(3-methylphenyl)-2-butensaeure-ethylester |