6-(4-(4-Methylthiazol-2-yl)-1H-imidazol-5-yl)benzo[d]thiazole hydrochloride
Modify Date: 2024-04-11 12:37:18
![6-(4-(4-Methylthiazol-2-yl)-1H-imidazol-5-yl)benzo[d]thiazole hydrochloride Structure](https://www.chemsrc.com/caspic/256/2459963-17-6.png)
6-(4-(4-Methylthiazol-2-yl)-1H-imidazol-5-yl)benzo[d]thiazole hydrochloride structure
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Common Name | 6-(4-(4-Methylthiazol-2-yl)-1H-imidazol-5-yl)benzo[d]thiazole hydrochloride | ||
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| CAS Number | 2459963-17-6 | Molecular Weight | 334.847 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H11ClN4S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 6-(4-(4-Methylthiazol-2-yl)-1H-imidazol-5-yl)benzo[d]thiazole hydrochlorideTP0427736 hydrochloride is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50=836 nM). TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. TP0427736 hydrochloride can be used for the research of androgenic alopecia (AGA)[1]. |
| Name | 6-(4-(4-Methylthiazol-2-yl)-1H-imidazol-5-yl)benzo[d]thiazole hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | TP0427736 hydrochloride is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50=836 nM). TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. TP0427736 hydrochloride can be used for the research of androgenic alopecia (AGA)[1]. |
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| Related Catalog | |
| References |
| Molecular Formula | C14H11ClN4S2 |
|---|---|
| Molecular Weight | 334.847 |
| Exact Mass | 334.011353 |
| Benzothiazole, 6-[4-(4-methyl-2-thiazolyl)-1H-imidazol-5-yl]-, hydrochloride (1:1) |
| 6-[4-(4-Methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole hydrochloride (1:1) |
| MFCD32633583 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: 6-(4-(4-Methylthiazol-2-yl)-1H-imidazol-5-yl)benzo[d]thiazole hydrochloride
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: TP0427736 hydrochloride
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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