5-Chloro-3-fluoro-2-pyridinamine

Modify Date: 2024-01-02 08:12:36

5-Chloro-3-fluoro-2-pyridinamine Structure
5-Chloro-3-fluoro-2-pyridinamine structure
Common Name 5-Chloro-3-fluoro-2-pyridinamine
CAS Number 246847-98-3 Molecular Weight 146.550
Density 1.5±0.1 g/cm3 Boiling Point 195.9±35.0 °C at 760 mmHg
Molecular Formula C5H4ClFN2 Melting Point 95-97℃
MSDS Chinese USA Flash Point 72.3±25.9 °C
Symbol GHS06 GHS09
GHS06, GHS09
Signal Word Danger

 Names

Name 2-Amino-5-chloro-3-fluoropyridine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 195.9±35.0 °C at 760 mmHg
Melting Point 95-97℃
Molecular Formula C5H4ClFN2
Molecular Weight 146.550
Flash Point 72.3±25.9 °C
Exact Mass 146.004700
PSA 38.91000
LogP 1.57
Vapour Pressure 0.4±0.4 mmHg at 25°C
Index of Refraction 1.576
Storage condition 2-8°C

 MSDS

Material Safety Data Sheet

Section1. Identification of the substance
Product Name: 2-Amino-5-chloro-3-fluoropyridine
Synonyms:5-Chloro-3-fluoropyridin-2-amine

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H301:Toxic if swallowed
H311:Toxic in contact with skin
H319:Causes serious eye irritation
Toxic if inhaled
H331:
H400:Very toxic to aquatic life
P261:Avoid breathing dust/fume/gas/mist/vapours/spray
P273:Avoid release to the environment
P280:Wear protective gloves/protective clothing/eye protection/face protection
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing
P311:Call a POISON CENTER or doctor/physician

Section3. Composition/information on ingredients.
Ingredient name:2-Amino-5-chloro-3-fluoropyridine
CAS number:246847-98-3

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
Eye contact:
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage:Store in closed vessels.

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Not specified
Appearance:
Boiling point:No data
Melting point:No data
Flash point:No data
Density:No data
Molecular formula: C5H4ClFN2
Molecular weight: 146.6

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride, hydrogen fluoride.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
UN Number:UN2811Class: 6.1Packing group: III
Proper shipping name: TOXIC SOLIDS, ORGANIC, N.O.S. (2-Amino-5-chloro-3-fluoropyridine)

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Symbol GHS06 GHS09
GHS06, GHS09
Signal Word Danger
Hazard Statements H301-H311-H319-H331-H400
Precautionary Statements P261-P273-P280-P301 + P310-P305 + P351 + P338-P311
Hazard Codes T,Xi
Risk Phrases 23/24/25-50
Safety Phrases 36/37-38-45-61-63
RIDADR UN 2811 6.1 / PGIII
HS Code 2933399090

 Synthetic Route

~%

5-Chloro-3-fluoro-2-pyridinamine Structure

5-Chloro-3-fluo...

CAS#:246847-98-3

Literature: US2006/47124 A1, ; Page/Page column 4 ; US 20060047124 A1

~76%

5-Chloro-3-fluoro-2-pyridinamine Structure

5-Chloro-3-fluo...

CAS#:246847-98-3

Literature: US2008/242695 A1, ; Page/Page column 34 ;

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2-Pyridinamine, 5-chloro-3-fluoro-
2-Amino-5-Chloro-3-Fluoropyridine
5-Chloro-3-fluoropyridin-2-amine
5-Chloro-3-fluoro-2-pyridinamine
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