GW 9578
Modify Date: 2024-01-10 18:19:26
GW 9578 structure
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Common Name | GW 9578 | ||
|---|---|---|---|---|
| CAS Number | 247923-29-1 | Molecular Weight | 492.622 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 641.7±55.0 °C at 760 mmHg | |
| Molecular Formula | C26H34F2N2O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 341.9±31.5 °C | |
Use of GW 9578GW9578 is a subtype-selective PPARα agonist (EC50s of 5 and 50 nM for murine and human PPAR-α) with potent lipid-lowering activity[1][2]. |
| Name | 2-[4-[2-[(2,4-difluorophenyl)carbamoyl-heptylamino]ethyl]phenyl]sulfanyl-2-methylpropanoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | GW9578 is a subtype-selective PPARα agonist (EC50s of 5 and 50 nM for murine and human PPAR-α) with potent lipid-lowering activity[1][2]. |
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| Related Catalog | |
| Target |
mouse PPARα:5 nM (EC50) h-PPARα:50 nM (EC50) |
| In Vitro | GW9578 exhibits activities on Murine PPAR-α, PPAR-γ, and PPAR-δ with EC50s of 0.005, 1.5, 2.6 μm, respectively. GW9578 exhibits activities on Human PPAR-α, PPAR-γ, and PPAR-δ with EC50s of 0.05, 1, and 1.4 μm, respectively[2]. Treatment of the CD8+ T-cell line, TK.1 cells with GW9578 (10 nM-1 μM; for 24 hours) is able to induce a dose-dependent increase in the amount of relative luciferase activity[3]. Treatment of murine T-cell thymoma EL-4 T cells with GW9578 (10 nM-10 μM; for 2 hours) leads to a significant decrease in IL-2 production compared with control cells[3]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 641.7±55.0 °C at 760 mmHg |
| Molecular Formula | C26H34F2N2O3S |
| Molecular Weight | 492.622 |
| Flash Point | 341.9±31.5 °C |
| Exact Mass | 492.225830 |
| PSA | 94.94000 |
| LogP | 6.87 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.574 |
| 2-{[4-(2-{[(2,4-Difluorophenyl)carbamoyl](heptyl)amino}ethyl)phenyl]sulfanyl}-2-methylpropanoic acid |
| gsk9578 |
| unii-h32abl87x4 |
| Propanoic acid, 2-[[4-[2-[[[(2,4-difluorophenyl)amino]carbonyl]heptylamino]ethyl]phenyl]thio]-2-methyl- |
| gw 9578 |