4-Hydroxymethylpyrazole

Modify Date: 2024-01-09 17:26:51

4-Hydroxymethylpyrazole structure	Common Name	4-Hydroxymethylpyrazole
	CAS Number	25222-43-9	Molecular Weight	98.103
	Density	1.3±0.1 g/cm3	Boiling Point	326.8±17.0 °C at 760 mmHg
	Molecular Formula	C₄H₆N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	151.5±20.9 °C

Use of 4-Hydroxymethylpyrazole

4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole (HY-B0876). Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase[1].

Name	1H-pyrazol-4-ylmethanol
Synonym	More Synonyms

Description	4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole (HY-B0876). Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase[1].
Related Catalog	Research Areas >> Others
Target	Human Endogenous Metabolite
References	[1]. R Blomstrand, et al. Pyrazoles as Inhibitors of Alcohol Oxidation and as Important Tools in Alcohol Research: An Approach to Therapy Against Methanol Poisoning. Proc Natl Acad Sci U S A . 1979 Jul;76(7):3499-503.

Density	1.3±0.1 g/cm3
Boiling Point	326.8±17.0 °C at 760 mmHg
Molecular Formula	C₄H₆N₂O
Molecular Weight	98.103
Flash Point	151.5±20.9 °C
Exact Mass	98.048012
PSA	48.91000
LogP	-0.87
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.590

Hazard Codes	Xi
HS Code	2933199090

Ethyl 4-pyrazol...

CAS#:37622-90-5

~75%

4-Hydroxymethyl...

CAS#:25222-43-9

Literature: Bur, Daniel; Gude, Markus; Hubschwerlen, Christian; Panchaud, Philippe Patent: US2013/96119 A1, 2013 ; Location in patent: Paragraph 1626; 1627 ;

(1-BENZYL-1H-PY...

CAS#:70817-17-3

4-Hydroxymethyl...

CAS#:25222-43-9

Literature: Journal of the American Chemical Society, , vol. 71, p. 4000

diazomethane

CAS#:186581-53-3

Diethyl ether

CAS#:60-29-7

Propargyl alcohol

CAS#:107-19-7

4-Hydroxymethyl...

CAS#:25222-43-9

Detail

Literature: Journal of the American Chemical Society, , vol. 71, p. 4000

Precursor 5
CAS#:37622-90-5 Ethyl 4-pyrazol... CAS#:70817-17-3 (1-BENZYL-1H-PY... CAS#:186581-53-3 diazomethane CAS#:60-29-7 Diethyl ether
CAS#:107-19-7 Propargyl alcohol
DownStream 0

HS Code	2933199090
Summary	2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%