Monastrol
Monastrol structure
|
Common Name | Monastrol | ||
|---|---|---|---|---|
| CAS Number | 254753-54-3 | Molecular Weight | 292.35 | |
| Density | 1.34g/cm3 | Boiling Point | 441.3ºC at 760mmHg | |
| Molecular Formula | C14H16N2O3S | Melting Point | 185-185.9ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 220.7ºC | |
Use of Monastrol(S)-Monastrol ((+)-Monastrol) is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cancer cell lines. (S)-Monastrol arrests mammalian cells in mitosis with monopolar spindles[1][2]. |
| Name | ethyl 4-(3-hydroxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate |
|---|---|
| Synonym | More Synonyms |
| Description | (S)-Monastrol ((+)-Monastrol) is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cancer cell lines. (S)-Monastrol arrests mammalian cells in mitosis with monopolar spindles[1][2]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.34g/cm3 |
|---|---|
| Boiling Point | 441.3ºC at 760mmHg |
| Melting Point | 185-185.9ºC(lit.) |
| Molecular Formula | C14H16N2O3S |
| Molecular Weight | 292.35 |
| Flash Point | 220.7ºC |
| Exact Mass | 292.08800 |
| PSA | 109.72000 |
| LogP | 1.92380 |
| Vapour Pressure | 2.13E-08mmHg at 25°C |
| Index of Refraction | 1.648 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: 100 mg/mL |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
|
Cytokinetic Failure-induced Tetraploidy Develops into Aneuploidy, Triggering Skin Aging in Phosphovimentin-deficient Mice.
J. Biol. Chem. 290 , 12984-98, (2015) Tetraploidy, a state in which cells have doubled chromosomal sets, is observed in ∼20% of solid tumors and is considered to frequently precede aneuploidy in carcinogenesis. Tetraploidy is also detecte... |
|
|
Loop 5-directed compounds inhibit chimeric kinesin-5 motors: implications for conserved allosteric mechanisms.
J. Thorac. Cardiovasc. Surg. 286 , 6201-10, (2011) The human Eg5 (HsEg5) protein is unique in its sensitivity to allosteric agents even among phylogenetic kin. For example, S-trityl-l-cysteine (STC) and monastrol are HsEg5 inhibitors that bind to a su... |
|
|
A sensitised RNAi screen reveals a ch-TOG genetic interaction network required for spindle assembly.
Sci. Rep. 5 , 10564, (2015) How multiple spindle assembly pathways are integrated to drive bipolar spindle assembly is poorly understood. We performed an image-based double RNAi screen to identify genes encoding Microtubule-Asso... |
| F3284-6466 |
| MFCD00813077 |
| monastrol |