Acetamide,2,2,2-trifluoro-N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-

Modify Date: 2024-01-08 11:37:26

Acetamide,2,2,2-trifluoro-N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]- structure	Common Name	Acetamide,2,2,2-trifluoro-N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
	CAS Number	26195-65-3	Molecular Weight	453.40800
	Density	1.36g/cm3	Boiling Point	681.3ºC at 760 mmHg
	Molecular Formula	C₂₂H₂₂F₃NO₆	Melting Point	N/A
	MSDS	N/A	Flash Point	365.8ºC

Name	N-Trifluoroacetyl Deacetylcolchicine
Synonym	More Synonyms

Density	1.36g/cm3
Boiling Point	681.3ºC at 760 mmHg
Molecular Formula	C₂₂H₂₂F₃NO₆
Molecular Weight	453.40800
Flash Point	365.8ºC
Exact Mass	453.14000
PSA	83.09000
LogP	3.80490
Vapour Pressure	2.05E-18mmHg at 25°C
Index of Refraction	1.555

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0910000

CHEMICAL NAME :: Colchicine, 17,17,17-trifluoro-

CAS REGISTRY NUMBER :: 26195-65-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H22-F3-N-O6

MOLECULAR WEIGHT :: 453.45

WISWESSER LINE NOTATION :: L B677 MV&T&J CO1 DO1 EO1 JMVXFFF NO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 844 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 456 ug/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,257,1981

2,2,2-trifluoro-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide